DR 抗原与类风湿性关节炎：对两个群体的研究。
DR antigens and rheumatoid arthritis: a study of two populations.
作者信息
Woodrow J C, Nichol F E, Zaphiropoulos G
出版信息
Br Med J (Clin Res Ed). 1981 Nov 14;283(6302):1287-8. doi: 10.1136/bmj.283.6302.1287.
Abstract
Thr prevalence of HLA-DR antigens was determined in a group of white patients with rheumatoid arthritis, similar patients originating from the Indian subcontinent, and corresponding controls. Rheumatoid arthritis was found to be highly associated with DR4 in the white patients but with DR1 in the Indian patients. These results raise the possibility that the DR antigens themselves do not play a part in increasing susceptibility to rheumatoid arthritis, but the locus for increased susceptibility is probably closely linked to the DR locus.
摘要
测定了一组患类风湿性关节炎的白人患者、来自印度次大陆的类似患者以及相应对照组中HLA - DR抗原的患病率。结果发现，类风湿性关节炎在白人患者中与DR4高度相关，而在印度患者中与DR1相关。这些结果增加了一种可能性，即DR抗原本身在增加类风湿性关节炎易感性方面并不起作用，但易感性增加的基因座可能与DR基因座紧密连锁。
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DR antigens and rheumatoid arthritis: a study of two populations.DR 抗原与类风湿性关节炎：对两个群体的研究。
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