针对不同革兰氏阴性菌脂多糖的不同免疫显性糖的单克隆抗体之间共享的独特型。
Shared idiotypes among monoclonal antibodies specific for different immunodominant sugars of lipopolysaccharide of different Gram-negative bacteria.
作者信息
Hiernaux J, Bona C A
出版信息
Proc Natl Acad Sci U S A. 1982 Mar;79(5):1616-20. doi: 10.1073/pnas.79.5.1616.
Abstract
Shared idiotypes (Ids) were identified on monoclonal antibodies specific for different immunodominant sugars in the lipopolysaccharide (LPS) of Gram-negative bacteria. The first group of monoclonal antibodies is specific for Escherichia coli 0113 LPS, whereas the second group is specific for Salmonella tranaroa LPS. The shared idiotopes borne by these two groups of monoclonal antibodies were identified with monoclonal anti-Id antibodies specific for E. coli LPS-binding monoclonal antibodies and with syngeneic anti-384Id antibodies specific for MOPC 384 and MOPC 870 myeloma proteins. Our data suggest that shared idiotopes are common for antibodies for an antigenic family.
摘要
在针对革兰氏阴性菌脂多糖（LPS）中不同免疫显性糖的单克隆抗体上鉴定出了共享独特型（Id）。第一组单克隆抗体对大肠杆菌O113 LPS具有特异性，而第二组对肠炎沙门氏菌LPS具有特异性。这两组单克隆抗体所携带的共享独特位，是用对大肠杆菌LPS结合单克隆抗体具有特异性的单克隆抗Id抗体，以及对MOPC 384和MOPC 870骨髓瘤蛋白具有特异性的同基因抗384Id抗体鉴定出来的。我们的数据表明，共享独特位对于一个抗原家族的抗体来说是常见的。
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Shared idiotypes among monoclonal antibodies specific for different immunodominant sugars of lipopolysaccharide of different Gram-negative bacteria.针对不同革兰氏阴性菌脂多糖的不同免疫显性糖的单克隆抗体之间共享的独特型。
Proc Natl Acad Sci U S A. 1982 Mar;79(5):1616-20. doi: 10.1073/pnas.79.5.1616.
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