人乳腺癌中的前列腺素
Prostaglandins in human mammary cancer.
作者信息
Watson D M, Kelly R W, Hawkins R A, Miller W R
出版信息
Br J Cancer. 1984 Apr;49(4):459-64. doi: 10.1038/bjc.1984.73.
Prostaglandins E2 and F2 alpha (PGE2 and PGF2 alpha) were measured by Gas Liquid Chromatography-Mass Spectrometry (GLC-MS) in extracts of 100 human mammary carcinomas. All tumours contained measurable amounts of both prostaglandins but wide variations between individual tumours were observed. Values for PGE2 ranged from 7 to 762 ng g-1 tissue with a median of 100 ng g-1 tissue. Values for PGF2 alpha ranged from 3 to 475 ng g-1 tissue (median 60 ng g-1 tissue). There was a highly significant positive correlation between amounts of the 2 prostaglandins in individual tumours. Amounts of both PGE2 and PGF2 alpha were not significantly related to the menopausal status of the patients or the presence of oestrogen and progesterone receptors.
采用气液色谱-质谱联用仪（GLC-MS）测定了100例人乳腺癌提取物中前列腺素E2和F2α（PGE2和PGF2α）的含量。所有肿瘤均含有可测量的两种前列腺素，但各肿瘤之间存在很大差异。PGE2的值在7至762 ng g-1组织之间，中位数为100 ng g-1组织。PGF2α的值在3至475 ng g-1组织之间（中位数为60 ng g-1组织）。单个肿瘤中这两种前列腺素的含量之间存在高度显著的正相关。PGE2和PGF2α的含量与患者的绝经状态或雌激素和孕激素受体的存在均无显著相关性。
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