Gaetani P, Butti G, Chiabrando C, Danova M, Castelli M G, Riccardi A, Assietti R, Paoletti P
Department of Surgery, Neurosurgery, University of Pavia, Policlinico S. Matteo, Italy.
J Neurooncol. 1991 Jun;10(3):233-40. doi: 10.1007/BF00177535.
The study of proliferative characteristics and biochemical aspects seem to be of great importance in order to define brain neoplastic behavior. The purpose of this study is to verify the existence of any possible correlation between Arachidonic Acid (AA) metabolism and proliferative characteristics in 30 meningiomas and 30 neuroepithelial tumors. The most represented metabolite in neuroepithelial tumors is TxB2, while 6-Keto-PGF1 alpha is the lowest represented product. Unimodal DNA distribution was observed in 66% of neuroepithelial tumors and in 87% of meningiomas. Aneuploidy was more frequent in glioblastomas and anaplastic meningiomas as previously reported; AA overall synthesis capacity and profile were similar between unimodal and bimodal cases of neuroepithelial tumors. Total AA metabolite, as well as TxB2 and PGD2, synthesis capacity are significantly higher in cases with S-phase cell percentage greater than or equal to 3% than in cases with S-phase % less than 3%. Total production of AA metabolites via the cyclooxygenase pathway is significantly higher in meningiomas with bimodal DNA distribution than in cases with unimodal DNA content; when considering S-phase cell percentage, similarly to what observed in neuroepithelial tumors, meningiomas with S% greater than 3% shows a significantly higher overall synthesis capacity for AA. AA metabolism capacity well correlates with proliferative patterns in neuroepithelial tumors: the relationship depends preferentially on TxB2 and PGD2 synthesis capacity. In cases of meningiomas, the amount of AA metabolites seem to be related to DNA content and proliferative activity when anaplastic features are histologically demonstrated.
为了明确脑肿瘤的行为，对其增殖特性和生化方面进行研究似乎非常重要。本研究的目的是验证30例脑膜瘤和30例神经上皮肿瘤中花生四烯酸（AA）代谢与增殖特性之间是否存在任何可能的相关性。神经上皮肿瘤中最具代表性的代谢产物是TxB2，而6-酮-前列环素F1α是含量最低的产物。在66%的神经上皮肿瘤和87%的脑膜瘤中观察到单峰DNA分布。如先前报道，非整倍体在胶质母细胞瘤和间变性脑膜瘤中更为常见；神经上皮肿瘤单峰和双峰病例的AA总体合成能力和谱相似。S期细胞百分比大于或等于3%的病例中，总AA代谢产物以及TxB2和PGD2的合成能力显著高于S期百分比小于3%的病例。通过环氧化酶途径产生的AA代谢产物总量在DNA分布为双峰的脑膜瘤中显著高于DNA含量为单峰的病例；考虑S期细胞百分比时，与神经上皮肿瘤中观察到的情况类似，S%大于3%的脑膜瘤显示出AA的总体合成能力显著更高。AA代谢能力与神经上皮肿瘤的增殖模式密切相关：这种关系主要取决于TxB2和PGD2的合成能力。在脑膜瘤病例中，当组织学显示有间变特征时，AA代谢产物的量似乎与DNA含量和增殖活性有关。
