Gallagher R P, Threlfall W J, Jeffries E, Band P R, Spinelli J, Coldman A J
J Natl Cancer Inst. 1984 Jun;72(6):1311-5.
For evaluation of occupational mortality in agriculture, age-standardized proportional mortality ratios (PMR) were calculated for 28,032 male farmers with the use of British Columbia (B.C.) death registrations collected from 1950 to 1978. Farmers had significantly elevated risks of death from cancer of the lip (PMR = 191, P = .05), stomach (PMR = 119, P less than .0001), and prostate gland (PMR = 113, P less than .001). In addition, leukemia was higher than expected (PMR = 122, P less than .01), as was aplastic anemia (PMR = 174, P less than .01). The elevated risks were fairly consistent over the 29-year period for stomach, prostate gland, and lip cancer, as well as for leukemia. The PMR for aplastic anemia was highest for the years 1950-59 and declined over the next 19 years. Farmers also showed significant mortality deficits for several important cancer sites, including esophagus (PMR = 59, P less than .0001), colon (PMR = 84, P less than .001), larynx (PMR = 62, P less than .01), and lung (PMR = 66, P less than .0001) for the period 1950-78. More detailed studies in B.C. will be necessary to confirm and extend these cancer-agriculture associations.
为评估农业领域的职业死亡率，利用1950年至1978年收集的不列颠哥伦比亚省（B.C.）死亡登记数据，计算了28,032名男性农民的年龄标准化比例死亡率（PMR）。农民患唇癌（PMR = 191，P = .05）、胃癌（PMR = 119，P < .0001）和前列腺癌（PMR = 113，P < .001）的死亡风险显著升高。此外，白血病（PMR = 122，P < .01）和再生障碍性贫血（PMR = 174，P < .01）的发病率也高于预期。在29年期间，胃癌、前列腺癌、唇癌以及白血病的风险升高情况相当一致。再生障碍性贫血的PMR在1950 - 1959年最高，在接下来的19年中有所下降。农民在包括食管（PMR = 59，P < .0001）、结肠（PMR = 84，P < .001）、喉（PMR = 62，P < .01）和肺（PMR = 66，P < .0001）在内的几个重要癌症部位的死亡率也显著低于预期，时间跨度为1950 - 1978年。有必要在不列颠哥伦比亚省进行更详细的研究，以确认并扩展这些癌症与农业之间的关联。
