b型流感嗜血杆菌对头孢克洛的敏感性及接种量的影响。
Susceptibility of Haemophilus influenzae type b to cefaclor and influence of inoculum size.
作者信息
Levin R M, Azimi P H, Dunphy M G
出版信息
Antimicrob Agents Chemother. 1982 Nov;22(5):923-5. doi: 10.1128/AAC.22.5.923.
Abstract
Cefaclor appeared to be an effective antibiotic against both beta-lactamase-positive and beta-lactamase-negative strains of Haemophilus influenzae type b when tested with 10(5) colony-forming units per ml. With inocula in excess of 10(6) colony-forming units per ml, these organisms were neither inhibited nor killed at concentrations of 400 micrograms/ml. This inoculum effect was also demonstrated in time-kill curve studies.
摘要
当每毫升接种10⁵个菌落形成单位进行测试时，头孢克洛似乎是一种对b型流感嗜血杆菌的β-内酰胺酶阳性和β-内酰胺酶阴性菌株均有效的抗生素。当接种量超过每毫升10⁶个菌落形成单位时，在400微克/毫升的浓度下，这些微生物既未受到抑制也未被杀死。这种接种量效应在时间-杀菌曲线研究中也得到了证实。
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