脂质过氧化与视网膜变性。
Lipid peroxidation and retinal degeneration.
作者信息
Anderson R E, Rapp L M, Wiegand R D
出版信息
Curr Eye Res. 1984 Jan;3(1):223-7. doi: 10.3109/02713688408997203.
PMID:6606531
Abstract
Retinal degenerations were produced in albino rats by exposure to constant illumination or in frogs and albino rats by intravitreal injections of ferrous sulfate. Both treatments resulted in the loss of long-chain polyunsaturated fatty acids and the accumulation of lipid hydroperoxides in isolated rod outer segments. We suggest that lipid peroxidation is a factor in certain types of retinal degenerations.
摘要
通过持续光照使白化大鼠产生视网膜变性，或通过向青蛙和白化大鼠玻璃体内注射硫酸亚铁使其产生视网膜变性。两种处理均导致分离的视杆细胞外段中长链多不饱和脂肪酸的丢失和脂质氢过氧化物的积累。我们认为脂质过氧化是某些类型视网膜变性的一个因素。
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