Diehl A K
JAMA. 1983 Nov 4;250(17):2323-6.
Gallstones are a major risk factor for gallbladder cancer, but few persons with stones experience development of tumors. To examine this relationship, a case-control study was performed. Each of 81 cancer cases was matched for age, sex, hospital, and admission date with two controls, one with benign gallbladder disease and one with a nongallbladder diagnosis. Persons with large gallstones were found to be at increased risk for cancer. For those with stone diameters of 2.0 to 2.9 cm, the odds ratio (v stone size less than 1 cm) was 2.4; for stones 3 cm or larger, the ratio was 10.1. This association of large gallstones with cancer was not hypothesized before data analysis and should be replicated in other settings before being accepted. If confirmed, however, this finding might have implications for the management of silent gallstones.
胆结石是胆囊癌的主要危险因素，但很少有胆结石患者会发展为肿瘤。为研究这种关系，开展了一项病例对照研究。81例癌症病例中的每一例，都在年龄、性别、医院和入院日期方面与两名对照进行匹配，一名对照患有良性胆囊疾病，另一名对照患有非胆囊疾病诊断。发现患有大胆结石的人患癌症的风险增加。对于结石直径为2.0至2.9厘米的人，比值比（与结石尺寸小于1厘米相比）为2.4；对于3厘米或更大的结石，比值比为10.1。这种大胆结石与癌症的关联在数据分析之前并未被假设，在被接受之前应在其他环境中重复验证。然而，如果得到证实，这一发现可能对无症状胆结石的管理具有启示意义。
