Violante M R, Thomson K R, Fischer H W, Kenyon T
Radiology. 1978 Aug;128(2):497-8. doi: 10.1148/128.2.497.
The toxicity of Renografin 76% was compared with that of Hypaque 76% by selective injection of each into the right coronary artery of dogs. Renografin contains the chelating agents sodium citrate and disodium edetate, while Hypaque contains calcium disodium edetate and no sodium citrate. Ventricular fibrillation occurred significantly more often with Renografin, suggesting that chelating agents contribute to toxicity in coronary angiography.
通过将76%的泛影葡胺和76%的碘他拉葡胺分别选择性注入狗的右冠状动脉，对二者的毒性进行了比较。泛影葡胺含有螯合剂柠檬酸钠和依地酸二钠，而碘他拉葡胺含有依地酸钙二钠且不含柠檬酸钠。使用泛影葡胺时室颤的发生率明显更高，这表明螯合剂在冠状动脉造影中会增加毒性。
