Wolf G L, Kraft L, Kilzer K
Radiology. 1978 Oct;129(1):215-7. doi: 10.1148/129.1.215.
Ventricular fibrillation thresholds were measured in anesthetized, closed-chest dogs during the injection of Renografin 76 or Conray 400 into the left coronary artery. Both agents significantly lowered fibrillation threshold--Renografin to 58 +/- 7%; Conray to 20 +/- 5% of control, respectively. The experimental method estimates fibrillatory potential of contrast media more precisely than previous methods. The initial results parallel relative toxicities observed in clinical usage.
在给麻醉的开胸狗的左冠状动脉注射泛影葡胺76或碘酞葡胺400的过程中，测量心室颤动阈值。两种药物均显著降低颤动阈值——泛影葡胺降至对照值的58±7%；碘酞葡胺分别降至对照值的20±5%。该实验方法比以往方法更精确地估计了造影剂的致颤潜力。初步结果与临床使用中观察到的相对毒性相符。
