Manifold I H, Bishop F M, Cloke P, Triger D R, Underwood J C
J Clin Pathol. 1982 Aug;35(8):815-9. doi: 10.1136/jcp.35.8.815.
Serum lysozyme activities and semiquantitative analysis of tissue lysozyme distribution were studied in patients with primary biliary cirrhosis (PBC), chronic hepatitis (CH), miscellaneous liver diseases, and normal subjects. Serum lysozyme was significantly raised in PBC and CH. Portal venous blood has similar lysozyme activities to peripheral venous blood in a group of various liver diseases. Lysozyme-containing intralobular cells were decreased in all liver diseases studied but portal tract lysozyme was increased only in PBC and CH. Thus the increase in serum lysozyme in PBC and CH appears to originate from the portal inflammatory infiltrate, seen in these diseases.
对原发性胆汁性肝硬化（PBC）、慢性肝炎（CH）、其他肝病患者及正常受试者的血清溶菌酶活性及组织溶菌酶分布的半定量分析进行了研究。PBC和CH患者的血清溶菌酶显著升高。在一组各种肝病患者中，门静脉血的溶菌酶活性与外周静脉血相似。在所研究的所有肝病中，含溶菌酶的小叶内细胞均减少，但仅在PBC和CH中门静脉区域的溶菌酶增加。因此，PBC和CH患者血清溶菌酶的升高似乎源于这些疾病中所见的门静脉炎性浸润。
