Brock-Utne J G, Dow T G, Welman S, Dimopoulos G E, Moshal M G
Anaesth Intensive Care. 1978 Feb;6(1):26-9. doi: 10.1177/0310057X7800600103.
The effects of intravenous metoclopramide (Maxolon) on the lower oesophageal sphincter (LOS) were studied in three groups of patients, one group being normal control and the other two being pregnant females, one without heartburn and the other with. Metoclopramide increases the LOS pressure 20.5, 15.2 and 10.2 cm H2O respectively (p less than 0.005, p less than 0.005 and p less than 0.05). These findings suggest that for patients undergoing elective or emergency obstetrical anaesthesia, intravenous metoclopramide may help reduce the incidence of regurgitation of gastric contents.
在三组患者中研究了静脉注射甲氧氯普胺（胃复安）对食管下括约肌（LOS）的影响，一组为正常对照组，另外两组为怀孕女性，一组无烧心症状，另一组有烧心症状。甲氧氯普胺分别使食管下括约肌压力升高20.5、15.2和10.2 cmH₂O（p<0.005、p<0.005和p<0.05）。这些发现表明，对于接受择期或急诊产科麻醉的患者，静脉注射甲氧氯普胺可能有助于降低胃内容物反流的发生率。
