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庆大霉素B半合成衍生物(Sch 21420)的体外评价

In vitro evaluation of a semisynthetic derivative of gentamicin B (Sch 21420).

作者信息

Yu P K, Washington J A

出版信息

Antimicrob Agents Chemother. 1978 May;13(5):891-2. doi: 10.1128/AAC.13.5.891.

DOI:10.1128/AAC.13.5.891
PMID:666309
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC352351/
Abstract

The activities of Sch 21420 and amikacin were compared in vitro against 448 clinical bacterial isolates and against 82 gentamicin-resistant isolates of gram-negative bacilli. At 1 mug/ml, Sch 21420 was more active than amikacin against most Enterobacteriaceae but less active against Pseudomonas aeruginosa. Activity of these antibiotics against gentamicin-resistant organisms varied according to the species examined.

摘要

在体外比较了Sch 21420和阿米卡星对448株临床分离菌以及82株革兰氏阴性杆菌庆大霉素耐药菌的活性。在1微克/毫升浓度下,Sch 21420对大多数肠杆菌科细菌的活性比阿米卡星强,但对铜绿假单胞菌的活性较弱。这些抗生素对庆大霉素耐药菌的活性因所检测的菌种而异。

相似文献

1
In vitro evaluation of a semisynthetic derivative of gentamicin B (Sch 21420).庆大霉素B半合成衍生物(Sch 21420)的体外评价
Antimicrob Agents Chemother. 1978 May;13(5):891-2. doi: 10.1128/AAC.13.5.891.
2
Bactericidal efficacy of Sch 20569 and amikacin against gentamicin-sensitive and -resistant organisms.Sch 20569和阿米卡星对庆大霉素敏感及耐药菌的杀菌效力
Antimicrob Agents Chemother. 1976 Apr;9(4):595-9. doi: 10.1128/AAC.9.4.595.
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In vitro activity of Sch 21420, derivative of gentamicin B, compared to that of amikacin.庆大霉素B衍生物Sch 21420与阿米卡星的体外活性比较。
Antimicrob Agents Chemother. 1978 Nov;14(5):786-7. doi: 10.1128/AAC.14.5.786.
4
Comparison of in vitro activity of Sch 21420, a gentamicin B derivative, with those of amikacin, gentamicin, netilmicin, sisomicin, and tobramycin.庆大霉素B衍生物Sch 21420与阿米卡星、庆大霉素、奈替米星、西索米星和妥布霉素的体外活性比较。
Antimicrob Agents Chemother. 1980 Aug;18(2):338-45. doi: 10.1128/AAC.18.2.338.
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Gentamicin and amikacin---an in vitro comparison using 1000 clinical isolates.庆大霉素与阿米卡星——使用1000株临床分离株进行的体外比较
Aust N Z J Med. 1978 Aug;8(4):383-6. doi: 10.1111/j.1445-5994.1978.tb04906.x.
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In vitro comparison of netilmicin, a semisynthetic derivative of sisomicin, and four other aminoglycoside antibiotics.西索米星半合成衍生物奈替米星与其他四种氨基糖苷类抗生素的体外比较。
Antimicrob Agents Chemother. 1976 Jul;10(1):139-45. doi: 10.1128/AAC.10.1.139.
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In vitro susceptibility of gentamicin-resistant Enterobacteriaceae and Pseudomonas aeruginosa to netilmicin and selected aminoglycoside antibiotics.庆大霉素耐药肠杆菌科细菌和铜绿假单胞菌对奈替米星及选定氨基糖苷类抗生素的体外敏感性
Antimicrob Agents Chemother. 1976 Oct;10(4):677-81. doi: 10.1128/AAC.10.4.677.
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In vitro activity of netilmicin, gentamicin, and amikacin.奈替米星、庆大霉素和阿米卡星的体外活性。
Antimicrob Agents Chemother. 1977 Jan;11(1):126-31. doi: 10.1128/AAC.11.1.126.
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Chemotherapeutic evaluation of 5-episisomicin (Sch 22591), a new semisynthetic aminoglycoside.新型半合成氨基糖苷类药物5-表异索霉素(Sch 22591)的化疗评估
Antimicrob Agents Chemother. 1978 Jan;13(1):41-8. doi: 10.1128/AAC.13.1.41.
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Comparative activity of netilmicin, gentamicin, amikacin, and tobramycin against Pseudomonas aeruginosa and Enterobacteriaceae.奈替米星、庆大霉素、阿米卡星和妥布霉素对铜绿假单胞菌和肠杆菌科细菌的比较活性。
Antimicrob Agents Chemother. 1976 Oct;10(4):592-7. doi: 10.1128/AAC.10.4.592.

引用本文的文献

1
Temporal variation in nephrotoxicity of low doses of isepamicin in rats.低剂量异帕米星对大鼠肾毒性的时间变化
Antimicrob Agents Chemother. 1996 Mar;40(3):802-6. doi: 10.1128/AAC.40.3.802.
2
Comparison of in vitro activity of Sch 21420, a gentamicin B derivative, with those of amikacin, gentamicin, netilmicin, sisomicin, and tobramycin.庆大霉素B衍生物Sch 21420与阿米卡星、庆大霉素、奈替米星、西索米星和妥布霉素的体外活性比较。
Antimicrob Agents Chemother. 1980 Aug;18(2):338-45. doi: 10.1128/AAC.18.2.338.
3
In vitro activity of Sch 21420, derivative of gentamicin B, compared to that of amikacin.庆大霉素B衍生物Sch 21420与阿米卡星的体外活性比较。
Antimicrob Agents Chemother. 1978 Nov;14(5):786-7. doi: 10.1128/AAC.14.5.786.
4
Comparative nephrotoxicity of SCH 21420 and amikacin in rats.SCH 21420与阿米卡星对大鼠的肾毒性比较
Antimicrob Agents Chemother. 1979 Oct;16(4):491-4. doi: 10.1128/AAC.16.4.491.