庆大霉素B半合成衍生物（Sch 21420）的体外评价
In vitro evaluation of a semisynthetic derivative of gentamicin B (Sch 21420).
作者信息
Yu P K, Washington J A
出版信息
Antimicrob Agents Chemother. 1978 May;13(5):891-2. doi: 10.1128/AAC.13.5.891.
Abstract
The activities of Sch 21420 and amikacin were compared in vitro against 448 clinical bacterial isolates and against 82 gentamicin-resistant isolates of gram-negative bacilli. At 1 mug/ml, Sch 21420 was more active than amikacin against most Enterobacteriaceae but less active against Pseudomonas aeruginosa. Activity of these antibiotics against gentamicin-resistant organisms varied according to the species examined.
摘要
在体外比较了Sch 21420和阿米卡星对448株临床分离菌以及82株革兰氏阴性杆菌庆大霉素耐药菌的活性。在1微克/毫升浓度下，Sch 21420对大多数肠杆菌科细菌的活性比阿米卡星强，但对铜绿假单胞菌的活性较弱。这些抗生素对庆大霉素耐药菌的活性因所检测的菌种而异。
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