Kabins S A, Nathan C
Antimicrob Agents Chemother. 1978 Nov;14(5):786-7. doi: 10.1128/AAC.14.5.786.
The minimal inhibitory concentration of Sch-21420 closely paralleled amikacin for 125 strains of aerobic gram-negative bacilli and Staphylococcus aureus primarily selected for testing because of resistance to other aminoglycoside antibiotics. Fifteen of 26 strains requiring 20 mug or more of amikacin per ml for inhibition were inhibited by two- to fourfold less Sch 21420. The majority of organisms resistant to both agents owed their resistance to mechanisms other than the carriage of aminoglycoside-modifying enzymes. Most strains carrying aminoglycoside 6'-acetyltransferase, capable of modifying amikacin, were susceptible to 10 mug or less of Sch 21420 per ml.
对于125株需氧革兰氏阴性杆菌和金黄色葡萄球菌，Sch-21420的最低抑菌浓度与阿米卡星非常接近。这些菌株主要是因为对其他氨基糖苷类抗生素耐药而被挑选用于测试。在每毫升需要20微克或更多阿米卡星才能抑制生长的26株菌株中，有15株对Sch 21420的敏感度高两倍到四倍。对这两种药物均耐药的大多数菌株，其耐药性源于氨基糖苷修饰酶携带以外的机制。大多数携带能够修饰阿米卡星的氨基糖苷6'-乙酰转移酶的菌株，对每毫升10微克或更低浓度的Sch 21420敏感。
