Maksimovich Ia B, Kresiun V I, Ariaev V L
Biull Eksp Biol Med. 1983 Aug;96(8):35-7.
The data on the efficacy of lithium nicotinate in therapy of experimental alcoholism are provided. The drug is capable of retarding the formation of alcoholic motivation. During treatment of psychic or physical alcoholic dependence, an antidepressant effect of the drug could be also seen. Under experimental acute alcoholic poisoning the drug attenuates the symptoms of intoxication. Antialcoholic effect of lithium nicotinate correlates with the normalization of the background EEG readings, activity of alcohol dehydrogenase, catalase, with the elevated content of the oxidized forms of NAD, NADP and the decreased level of malonic dialdehyde. The possibility of using lithium nicotinate as an antialcoholic drug is discussed.
提供了有关烟酸锂治疗实验性酒精中毒疗效的数据。该药物能够延缓酒精性动机的形成。在治疗精神性或生理性酒精依赖期间，还可观察到该药物的抗抑郁作用。在实验性急性酒精中毒情况下，该药物可减轻中毒症状。烟酸锂的抗酒精作用与背景脑电图读数、酒精脱氢酶、过氧化氢酶活性的正常化相关，与NAD、NADP氧化形式含量升高以及丙二醛水平降低相关。讨论了使用烟酸锂作为抗酒精药物的可能性。
