用利巴韦林的亲脂性衍生物治疗小鼠颅内登革病毒感染。
Treatment of intracranial dengue virus infections in mice with a lipophilic derivative of ribavirin.
作者信息
Koff W C, Pratt R D, Elm J L, Venkateshan C N, Halstead S B
出版信息
Antimicrob Agents Chemother. 1983 Jul;24(1):134-6. doi: 10.1128/AAC.24.1.134.
Abstract
Rimantadine, ribavirin, and 6-mercapto-9-(tetrahydro-2-furyl)purine, administered intraperitoneally every 8 h for 7 days starting minutes after virus challenge, had no effect on survival and mean survival time of BALB/c mice inoculated intracranially with dengue virus type 2. In contrast, intraperitoneal treatment with ribavirin 2',3',5'-triacetate, a lipophilic analog of ribavirin, effected significant increases in both mean survival time and survival rate, suggesting that ribavirin 2',3',5'-triacetate may be superior to rabavirin for treatment of viral diseases of the brain.
摘要
金刚乙胺、利巴韦林和6-巯基-9-(四氢-2-呋喃基)嘌呤，在病毒攻击后数分钟开始，每8小时腹腔注射一次，持续7天，对经颅内接种2型登革病毒的BALB/c小鼠的存活和平均存活时间没有影响。相比之下，用利巴韦林的亲脂性类似物2',3',5'-三乙酰利巴韦林进行腹腔治疗，可使平均存活时间和存活率显著增加，这表明2',3',5'-三乙酰利巴韦林在治疗脑部病毒性疾病方面可能优于利巴韦林。
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