鼠冠状病毒MHV - A59核衣壳基因序列
Sequence of the nucleocapsid gene from murine coronavirus MHV-A59.
作者信息
Armstrong J, Smeekens S, Rottier P
出版信息
Nucleic Acids Res. 1983 Feb 11;11(3):883-91. doi: 10.1093/nar/11.3.883.
Abstract
The nucleotide sequence of the RNA encoding the nucleocapsid protein of coronavirus MHV-A59 has been determined. Copy DNA was prepared from mRNA isolated from virally infected cells, fragmented and cloned in the phage vector M13 mp8 for direct sequence determination. A sequence of 1817 nucleotides, adjacent to the viral poly-A tail, was obtained. It contains a single long open reading frame encoding a protein of mol. wt. 49660, which is enriched in basic residues.
摘要
已确定编码冠状病毒MHV - A59核衣壳蛋白的RNA的核苷酸序列。从病毒感染细胞中分离出的mRNA制备了互补DNA，将其片段化并克隆到噬菌体载体M13 mp8中以进行直接序列测定。获得了与病毒多聚腺苷酸尾相邻的1817个核苷酸的序列。它包含一个单一的长开放阅读框，编码一种分子量为49660的蛋白质，该蛋白质富含碱性残基。
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