结节病患者血清D-阿拉伯糖醇水平升高。
Elevated serum D-arabinitol levels in patients with sarcoidosis.
作者信息
Karam G H, Elliott A M, Polt S, Cobbs C G
出版信息
J Clin Microbiol. 1984 Jan;19(1):26-9. doi: 10.1128/jcm.19.1.26-29.1984.
D-Arabinitol has been found in the serum of patients with candidiasis in an incidence varying from 38 to 82%. While screening serum by gas chromatography for the presence of this sugar, we observed elevated concentrations in several patients with sarcoidosis. In an attempt to determine the significance of this chance observation, we tested serum from additional patients with sarcoidosis along with serum from patients with other clinical conditions known to be associated with elevated D-arabinitol levels. Of 53 patients with sarcoidosis, 27 (51%) had elevated concentrations of this compound. Only one of these patients had decreased renal function (creatinine, 2.5 mg/dl). We were unable to correlate elevated values with extent of the disease. Although the significance of this finding is not clear, it may represent a clue to the pathogenesis of sarcoidosis.
已在念珠菌病患者的血清中发现D -阿拉伯糖醇，其发生率在38%至82%之间。在用气相色谱法筛查血清中这种糖的存在时，我们在几名结节病患者中观察到其浓度升高。为了确定这一偶然发现的意义，我们检测了更多结节病患者的血清以及已知与D -阿拉伯糖醇水平升高相关的其他临床疾病患者的血清。在53名结节病患者中，27名（51%）该化合物浓度升高。这些患者中只有一名肾功能下降（肌酐，2.5mg/dl）。我们无法将升高的值与疾病程度相关联。尽管这一发现的意义尚不清楚，但它可能为结节病的发病机制提供线索。
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