Woolf I L, El Sheikh N, Cullens H, Eddleston A L, Williams R
Digestion. 1978 Jul-Aug;17(4):317-22. doi: 10.1159/000198125.
58 patients with acute hepatitis type B, including 13 with fulminant hepatitis, were tested on presentation for HBeAg. Positive results were obtained in 24%. The frequency was highest in those with fulminant hepatitis (46% positive), and this was probably related to the earlier presentation of patients with this condition. Patients with acute hepatitis who were HBeAg-positive had had a significantly shorter duration of symptoms than those who were HBeAg-negative at presentation. HBeAg was still detectable more than 3 weeks after the onset of symptoms in only 2 patients, both of whom progressed to chronic active hepatitis. The early detection of HBeAg in patients with acute hepatitis is of no prognostic significance, but its persistence may provide the earliest evidence of potential chronicity.
58例急性乙型肝炎患者，其中13例为暴发性肝炎，在就诊时检测HBeAg。24%的患者结果呈阳性。暴发性肝炎患者的阳性率最高（46%呈阳性），这可能与该病情患者就诊较早有关。急性肝炎患者中HBeAg阳性者症状持续时间明显短于就诊时HBeAg阴性者。仅2例患者在症状出现3周后仍可检测到HBeAg，这2例患者均进展为慢性活动性肝炎。急性肝炎患者中HBeAg的早期检测无预后意义，但其持续存在可能是潜在慢性化的最早证据。
