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灵长类动物行放射状角膜切开术后的皮质类固醇治疗。

Corticosteroid therapy after anterior radial keratotomy in Primates.

作者信息

Yamaguchi T, Asbell P A, Ostrick M, Kissling G E, Safir A, Kaufman H E

出版信息

Am J Ophthalmol. 1984 Feb;97(2):215-20. doi: 10.1016/s0002-9394(14)76093-3.

Abstract

Anterior radial keratotomy was performed on nine Green monkey eyes. Four of these eyes received subconjunctival corticosteroid injections immediately after surgery and three times thereafter at three-week intervals. Two eyes received subconjunctival physiologic salt solution injections on the same schedule. Three eyes received no injections after surgery. Although endothelial cell loss in the first week after surgery was reduced in the drug-treated eyes, there were no statistically significant differences in cell densities at nine months after surgery. Corticosteroid therapy after anterior radial keratotomy appeared to confer no long-range benefits in terms of the numbers of corneal endothelial cells in these primate eyes.

摘要

对九只绿猴眼进行了放射状角膜切开术。其中四只眼在手术后立即接受了结膜下皮质类固醇注射,此后每隔三周注射三次。两只眼按相同的时间表接受了结膜下生理盐溶液注射。三只眼在手术后未接受注射。尽管药物治疗的眼睛在术后第一周内皮细胞损失有所减少,但在术后九个月时细胞密度没有统计学上的显著差异。在前房放射状角膜切开术后,皮质类固醇治疗在这些灵长类动物眼中的角膜内皮细胞数量方面似乎没有带来长期益处。

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