Yamaguchi T, Asbell P A, Ostrick M, Safir A, Kissling G E, Kaufman H E
Arch Ophthalmol. 1984 May;102(5):765-9. doi: 10.1001/archopht.1984.01040030613033.
Anterior radial keratotomy was performed with a diamond blade in ten rhesus monkey eyes. Results were compared with those of a previous study in which a metal blade was used. Histologic assessment showed endothelial degeneration, but fewer edematous endothelial cells, than in the previous study. Specular microscopy demonstrated statistically significant endothelial cell losses (7.99%), when preoperative and three-month postoperative values were compared. Autoradiography showed little cell division in the endothelial cell layer. Cell loss seemed to be repaired mainly by the spreading of neighboring cells. Endothelial cell division is also limited in humans, and the cumulative loss of cells due to surgical trauma combined with continuous damage-related losses and later age-related reductions in cell numbers could produce corneal decompensation in some patients years after radial keratotomy.
用钻石刀片对十只恒河猴眼进行了前房放射状角膜切开术。将结果与之前使用金属刀片的研究结果进行了比较。组织学评估显示内皮细胞变性，但与之前的研究相比，水肿的内皮细胞较少。角膜内皮显微镜检查显示，术前和术后三个月的值进行比较时，内皮细胞损失具有统计学意义（7.99%）。放射自显影显示内皮细胞层几乎没有细胞分裂。细胞损失似乎主要通过相邻细胞的扩散来修复。内皮细胞分裂在人类中也受到限制，手术创伤导致的细胞累积损失，加上与持续损伤相关的损失以及后期与年龄相关的细胞数量减少，可能会在放射状角膜切开术数年之后导致一些患者的角膜失代偿。
