Baskanchiladze G Sh, Khurtsilava L A, Gelovani I A, Asatiani M V, Rossinskii V I
Antibiotiki. 1984 Jan;29(1):33-5.
The efficacy of papain, a proteolytic enzyme made in the USSR, was studied alone and in combination with antibiotics, such as benzylpenicillin, streptomycin, chloramphenicol, tetracycline, erythromycin and novobiocin in treatment of mice with septicemia caused by antibiotic-resistant staphylococci. It was shown that the enzyme increased the chemotherapeutic efficacy of the antibiotics on the average by 50 per cent. When used alone in a dose of 0.1 mg per mouse papain prevented death in 20 per cent of animals. The high chemotherapeutic efficacy of the antibiotic combinations with papain allowed recommending it for use in clinical practice for the treatment of infections caused by antibiotic-resistant staphylococci.
对苏联生产的一种蛋白水解酶——木瓜蛋白酶，单独使用以及与抗生素（如苄青霉素、链霉素、氯霉素、四环素、红霉素和新生霉素）联合使用治疗由耐抗生素葡萄球菌引起败血症的小鼠的疗效进行了研究。结果表明，该酶可使抗生素的化疗效果平均提高50%。当以每只小鼠0.1毫克的剂量单独使用时，木瓜蛋白酶可使20%的动物免于死亡。抗生素与木瓜蛋白酶联合使用具有很高的化疗效果，因此建议在临床实践中用于治疗由耐抗生素葡萄球菌引起的感染。
