Bukharin O V, Zak V I, Kurlaev P P, Zykova L S
Antibiotiki. 1984 May;29(5):365-9.
The antimicrobial effect of oxytocin in combination with 39 antibacterial drugs was studied in vitro with the use of 30 strains of different test cultures. It was shown that oxytocin had a capacity for potentiating the antibiotic effect on many microbial species. The potentiation ratio depended on the antibiotic and microbial species used and ranged from 2 to 24 times. The combined therapy with oxytocin and antibiotics was tested on animals with experimental staphylococcal sepsis. The survival rate of more than 50 per cent was observed only in the group of animals treated with the combinations of antibiotics and oxytocin, while in the other groups the death rate amounted to 100 per cent. The most favourable combinations of oxytocin and antibiotics were used in the treatment of 260 patients with pyoinflammatory affections of the soft tissues (mastitis, postinfection suppuration, paraproctitis, etc). In the majority of cases, the surgical treatment was replaced by the paracentetic treatment with local application of the combinations of oxytocin and antibiotics. This markedly decreased (by 3-4 times) the periods of temporary disability, provided better cosmetic results of the treatment and lowered consumption of the dressing material.
利用30株不同的试验培养菌，在体外研究了催产素与39种抗菌药物联合使用时的抗菌效果。结果表明，催产素具有增强许多微生物对抗生素敏感性的能力。增效比取决于所使用的抗生素和微生物种类，范围为2至24倍。在患有实验性葡萄球菌败血症的动物身上测试了催产素与抗生素的联合治疗。仅在使用抗生素与催产素联合治疗的动物组中观察到超过50%的存活率，而在其他组中死亡率达100%。催产素与抗生素的最有效组合用于治疗260例软组织脓性炎症（乳腺炎、感染后化脓、肛周直肠炎等）患者。在大多数情况下，手术治疗被局部应用催产素与抗生素组合的穿刺治疗所取代。这显著缩短了（3至4倍）暂时丧失劳动能力的时间，提供了更好的治疗美容效果，并减少了敷料材料的消耗。
