顺式不饱和脂肪酸使完整淋巴细胞中的线粒体解偶联并刺激糖酵解。
cis-Unsaturated fatty acids uncouple mitochondria and stimulate glycolysis in intact lymphocytes.
作者信息
Arslan P, Corps A N, Hesketh T R, Metcalfe J C, Pozzan T
出版信息
Biochem J. 1984 Jan 15;217(2):419-25. doi: 10.1042/bj2170419.
Abstract
In intact lymphocytes, linoleic acid acts as a typical mitochondrial uncoupler: it substantially decreases the mitochondrial membrane potential and the cellular ATP level, while stimulating oxygen consumption and glycolysis. Under these conditions the inhibition of cellular functions by linoleic acid cannot be attributed to its postulated effects on lipid domains in the plasma membrane.
摘要
在完整的淋巴细胞中，亚油酸起着典型的线粒体解偶联剂的作用：它能显著降低线粒体膜电位和细胞ATP水平，同时刺激氧消耗和糖酵解。在这些条件下，亚油酸对细胞功能的抑制不能归因于其对质膜脂质结构域的假定作用。
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