白血病牛血清中抗体对牛白血病病毒逆转录酶的抑制作用及该酶的免疫学特性
Inhibition of the reverse transcriptase of bovine leukemia virus by antibody in sera from leukemic cattle and immunological characterization of the enzyme.
作者信息
Wuu K D, Graves D C, Ferrer J F
出版信息
Cancer Res. 1977 May;37(5):1438-42.
Sera from some leukemic cattle contain an antibody that inhibits the reverse transcriptase activity of the bovine leukemia virus. The antibody is not directed against the synthetic template or the major internal and envelope viral antigens. The antibody failed to inhibit the DNA polymerases of the murine leukemia virus, simian sarcoma-associated virus, avian myeloblastosis virus, or Escherichia coli. Conversely, the bovine leukemia virus enzyme was not inhibited by antibody against the reverse transcriptases of other C-type viruses. These findings agree with previous results showing that the major internal bovine leukemia virus protein lacks the known interspecies- and intraspecies-specific antigenic determinants indentified in the homologous proteins of other oncornaviruses.
一些患白血病牛的血清中含有一种抗体，该抗体可抑制牛白血病病毒的逆转录酶活性。这种抗体并非针对合成模板或主要的内部及包膜病毒抗原。该抗体无法抑制鼠白血病病毒、猿猴肉瘤相关病毒、禽成髓细胞瘤病毒或大肠杆菌的DNA聚合酶。相反，牛白血病病毒酶也不会被针对其他C型病毒逆转录酶的抗体所抑制。这些发现与之前的结果一致，即牛白血病病毒主要内部蛋白缺乏在其他肿瘤病毒同源蛋白中所确定的已知种间和种内特异性抗原决定簇。
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