抑制人类免疫缺陷病毒逆转录酶并与无法分离病毒相关的抗体。
Antibody that inhibits human immunodeficiency virus reverse transcriptase and association with inability to isolate virus.
作者信息
Sano K, Lee M H, Morales F, Nishanian P, Fahey J, Detels R, Imagawa D T
机构信息
Department of Pediatrics, Harbor-UCLA Medical Center, Torrance 90509.
出版信息
J Clin Microbiol. 1987 Dec;25(12):2415-7. doi: 10.1128/jcm.25.12.2415-2417.1987.
Abstract
Most individuals infected with human immunodeficiency virus (HIV), the causative agent of acquired immune deficiency syndrome, produce an antibody against the viral reverse transcriptase (RT). Our studies show that 67% of HIV-seropositive individuals (33 of 49) produced an antibody that specifically inhibited viral RT enzyme activity. We were able to isolate HIV from only 18% of these individuals (6 of 33). On the other hand, virus was readily isolated from 63% of HIV-seropositive individuals (10 of 16) who did not demonstrate this antibody. Further examination of this RT-inhibiting antibody and its role during virus infection is needed, as it may prove to be of diagnostic, prognostic, or therapeutic value in this study and treatment of acquired immune deficiency syndrome.
摘要
大多数感染人类免疫缺陷病毒（HIV，获得性免疫缺陷综合征的病原体）的个体都会产生针对病毒逆转录酶（RT）的抗体。我们的研究表明，67%的HIV血清阳性个体（49例中的33例）产生了一种能特异性抑制病毒RT酶活性的抗体。我们仅能从这些个体中的18%（33例中的6例）分离出HIV。另一方面，在未表现出这种抗体的HIV血清阳性个体中，63%（16例中的10例）很容易分离出病毒。需要进一步研究这种RT抑制抗体及其在病毒感染过程中的作用，因为它可能在获得性免疫缺陷综合征的研究和治疗中具有诊断、预后或治疗价值。
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