Kergonou J F, Bernard P, Braquet M, Rocquet G
Biochimie. 1981 Jun;63(6):555-9. doi: 10.1016/s0300-9084(81)80088-0.
In this work, we studied the influence of whole-body gamma irradiation (800 rads) upon malonaldehyde (MDA) content in plasma, erythrocyte, brain, heart, lung, kidney, spleen, liver, thymus and bone marrow. MDA levels were increased in all studied samples, except lung; the highest increases were observed in the most radiosensitive organs (bone marrow, thymus, spleen) and not in those continuously exposed to high concentrations of molecular oxygen (lungs, erythrocytes). Comparison of the variations of MDA levels in plasma, kidneys and spleen to those in the other tissues lead to the hypothesis that MDA is released from tissues in plasma and trapped from plasma in kidney and spleen. The variations in plasma and erythrocyte were found not to be related to each other.
在本研究中，我们研究了全身γ射线照射（800拉德）对血浆、红细胞、脑、心脏、肺、肾脏、脾脏、肝脏、胸腺和骨髓中丙二醛（MDA）含量的影响。除肺外，所有研究样本中的MDA水平均升高；在最放射敏感的器官（骨髓、胸腺、脾脏）中观察到最高的升高，而在持续暴露于高浓度分子氧的器官（肺、红细胞）中则未观察到。将血浆、肾脏和脾脏中MDA水平的变化与其他组织中的变化进行比较，得出了这样的假设：MDA从组织释放到血浆中，并在肾脏和脾脏中从血浆中捕获。发现血浆和红细胞中的变化彼此无关。
