口服奥沙西泮后人体血浆皮质醇的抑制作用。
Suppression of plasma cortisol after oral administration of oxazepam in man.
作者信息
Gram L F, Christensen L, Kristensen C B, Kragh-Sorensen P
出版信息
Br J Clin Pharmacol. 1984 Feb;17(2):176-8. doi: 10.1111/j.1365-2125.1984.tb02335.x.
Abstract
In seven healthy male subjects plasma cortisol was measured at 20 min intervals from 07.00 to 13.00 h, during a drug free control test and after oral administration of 30 and 60 mg oxazepam. A significant suppression of the plasma cortisol levels for about 2 h after 30 mg oxazepam, and for about 3 h after 60 mg oxazepam was observed. The suppression wore off before the oxazepam plasma concentration started to decline significantly.
摘要
在七名健康男性受试者中，于无药物对照试验期间以及口服30毫克和60毫克奥沙西泮后，从07:00至13:00每隔20分钟测量一次血浆皮质醇。观察到服用30毫克奥沙西泮后约2小时以及服用60毫克奥沙西泮后约3小时，血浆皮质醇水平出现显著抑制。在奥沙西泮血浆浓度开始显著下降之前，这种抑制作用逐渐消失。
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