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口服奥沙西泮后人体血浆皮质醇的抑制作用。

Suppression of plasma cortisol after oral administration of oxazepam in man.

作者信息

Gram L F, Christensen L, Kristensen C B, Kragh-Sorensen P

出版信息

Br J Clin Pharmacol. 1984 Feb;17(2):176-8. doi: 10.1111/j.1365-2125.1984.tb02335.x.

DOI:10.1111/j.1365-2125.1984.tb02335.x
PMID:6704288
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1463316/
Abstract

In seven healthy male subjects plasma cortisol was measured at 20 min intervals from 07.00 to 13.00 h, during a drug free control test and after oral administration of 30 and 60 mg oxazepam. A significant suppression of the plasma cortisol levels for about 2 h after 30 mg oxazepam, and for about 3 h after 60 mg oxazepam was observed. The suppression wore off before the oxazepam plasma concentration started to decline significantly.

摘要

在七名健康男性受试者中，于无药物对照试验期间以及口服30毫克和60毫克奥沙西泮后，从07:00至13:00每隔20分钟测量一次血浆皮质醇。观察到服用30毫克奥沙西泮后约2小时以及服用60毫克奥沙西泮后约3小时，血浆皮质醇水平出现显著抑制。在奥沙西泮血浆浓度开始显著下降之前，这种抑制作用逐渐消失。

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本文引用的文献

1
Overdosage of antidepressants: clinical and pharmacokinetic aspects.抗抑郁药过量：临床与药代动力学方面
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Afternoon plasma cortisol in depressed patients: a measure of diagnosis or severity?
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The effects of diazepam on sleep, and on the nocturnal release of growth hormone, prolactin, ACTH and cortisol.地西泮对睡眠以及生长激素、催乳素、促肾上腺皮质激素和皮质醇夜间释放的影响。
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