Bowmer C J, Clarke C A, Comer M B, Yates M S
Br J Pharmacol. 1984 Jan;81(1):69-73. doi: 10.1111/j.1476-5381.1984.tb10745.x.
The vascular reactivity of rats with glycerol-induced acute renal failure was assessed in vitro and in vivo. The contractile responses to noradrenaline, angiotensin and potassium chloride of aortic strips and portal vein segments from uraemic rats were significantly smaller than the responses obtained in vessels from control animals. The pressor responses to angiotensin were reduced significantly in rats with acute renal failure when compared to those in control rats. The reduced vascular responses to a range of spasmogens suggests that in this model of renal failure there is a defect in some mechanism of vascular contraction common to all three constrictor agents.
在体外和体内评估了甘油诱导的急性肾衰竭大鼠的血管反应性。尿毒症大鼠主动脉条和门静脉段对去甲肾上腺素、血管紧张素和氯化钾的收缩反应明显小于对照动物血管的反应。与对照大鼠相比，急性肾衰竭大鼠对血管紧张素的升压反应显著降低。对一系列致痉剂的血管反应降低表明，在这种肾衰竭模型中，所有三种收缩剂共同的血管收缩机制存在缺陷。
