Benowitz N L, Jacob P
Clin Pharmacol Ther. 1984 Apr;35(4):499-504. doi: 10.1038/clpt.1984.67.
Daily intake of nicotine in 22 subjects was estimated from metabolic clearance data obtained after intravenous infusion of nicotine and from blood and urinary nicotine concentration data obtained over 24 hr when the subjects were smoking cigarettes. Daily intake of nicotine averaged 37.6 mg (+/- 17.7, SD) but varied widely among subjects (10.5 to 78.6 mg). Men metabolized nicotine faster than did women, but daily intake of nicotine did not differ. Intake correlated strongly with cigarettes smoked per day (r = 0.59) but not with machine-determined yield. Nicotine intake per cigarette averaged 1.04 mg (+/- 0.36) but did not correlate with machine-determined yield. Correlations between several commonly used biochemical markers of tobacco smoke and nicotine intake were examined; the afternoon (4:00 P.M.) blood level of nicotine was the best marker.
根据静脉输注尼古丁后获得的代谢清除数据以及受试者吸烟时24小时内的血液和尿液尼古丁浓度数据，估算了22名受试者的每日尼古丁摄入量。尼古丁的每日摄入量平均为37.6毫克（±17.7，标准差），但受试者之间差异很大（10.5至78.6毫克）。男性代谢尼古丁的速度比女性快，但每日尼古丁摄入量没有差异。摄入量与每日吸烟量密切相关（r = 0.59），但与机器测定的产量无关。每支香烟的尼古丁摄入量平均为1.04毫克（±0.36），但与机器测定的产量无关。研究了几种常用的烟草烟雾生化标志物与尼古丁摄入量之间的相关性；下午4点的血液尼古丁水平是最佳标志物。
