肺结核患者血清淀粉样蛋白A和C反应蛋白水平：与淀粉样变性的关系
Serum amyloid A protein and C-reactive protein levels in pulmonary tuberculosis: relationship to amyloidosis.
作者信息
de Beer F C, Nel A E, Gie R P, Donald P R, Strachan A F
出版信息
Thorax. 1984 Mar;39(3):196-200. doi: 10.1136/thx.39.3.196.
C-reactive protein and serum amyloid A protein levels were measured in 54 patients with pulmonary tuberculosis. The primary tuberculous complex was associated with an insignificant acute phase response, while post-primary tuberculosis without evidence of lung destruction caused modest increases in C-reactive protein and serum amyloid A protein. In most patients with post-primary pulmonary tuberculosis with significant pulmonary destruction there was a major acute phase response, with very high serum amyloid A protein and C-reactive protein levels. The response in these patients is most likely to be due to secondary bacterial infection in addition to infection by Mycobacterium tuberculosis. Patients with miliary tuberculosis showed a major acute phase response. Serum amyloid A protein and C-reactive protein levels decreased rapidly after initiation of treatment in the patients with post-primary tuberculosis without significant pulmonary destruction.
对54例肺结核患者测定了C反应蛋白和血清淀粉样蛋白A水平。原发性结核综合征与不显著的急性期反应相关，而无肺部破坏证据的原发性后结核病导致C反应蛋白和血清淀粉样蛋白A有适度升高。在大多数有显著肺部破坏的原发性后肺结核患者中，存在主要的急性期反应，血清淀粉样蛋白A和C反应蛋白水平非常高。这些患者的反应很可能除了结核分枝杆菌感染外，还归因于继发性细菌感染。粟粒性肺结核患者表现出主要的急性期反应。在无显著肺部破坏的原发性后结核病患者开始治疗后，血清淀粉样蛋白A和C反应蛋白水平迅速下降。
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