Goffinet A M
J Anat. 1984 Mar;138 ( Pt 2)(Pt 2):207-15.
The architectonics and development of the facial nerve nucleus have been compared in reeler and normal mice. In both genotypes neurons were generated at E10, and their axons entered the facial nerve at E11. Cell bodies migrated radially at E12-E13, possibly along radial neuroepithelial fibres. From the end of migration, the reeler nucleus was less superficially located and less clearly organised than the normal nucleus. The normal adult architectonic divisions were present in the mutant, but less distinct than in the normal nucleus. These observations have been related to other data on the developmental biology of the reeler brain. It is suggested that the reeler gene could affect an interaction between neurons or between neurons and radial fibres at the end of migration.
已对Reeler小鼠和正常小鼠的面神经核的构筑和发育进行了比较。在两种基因型中，神经元均于胚胎第10天生成，其轴突于胚胎第11天进入面神经。细胞体在胚胎第12 - 13天沿放射状迁移，可能是沿着放射状神经上皮纤维迁移。从迁移结束时起，Reeler小鼠的面神经核比正常核位置更深，且组织结构更不清晰。突变体中存在正常成年期的构筑分区，但不如正常核明显。这些观察结果与关于Reeler小鼠大脑发育生物学的其他数据相关。有人提出，Reeler基因可能在迁移结束时影响神经元之间或神经元与放射状纤维之间的相互作用。
