McGinn M D, Chole R A, Henry K R
Acta Otolaryngol. 1984 Mar-Apr;97(3-4):297-304. doi: 10.3109/00016488409130992.
Surgical ligation of the external auditory canals of Mongolian gerbils produces aural cholesteatomas that are similar to spontaneous gerbilline cholesteatomas. These experimental cholesteatomas expand rapidly, medially displacing the tympanic membrane and eroding bone. Less than 2 months after ligation, half these cholesteatomas are in contact with the bony prominence of the cochlea. Ligation-induced formation of cholesteatomas may be unique to the gerbil. Keratin deposits are produced by similar ligations of the external auditory canals of cats, guinea pigs, hamsters, mice, and rats. However, in these animals there is no medial displacement of the tympanic membrane, no cholesteatoma formation, and no bone erosion. Cholesteatomas were not seen in cats, guinea pigs, hamsters, mice, and rats even after post-ligation intervals of 6 to 36 months.
对蒙古沙鼠的外耳道进行手术结扎会产生耳胆脂瘤，这些耳胆脂瘤与沙鼠自发的胆脂瘤相似。这些实验性胆脂瘤迅速扩大，使鼓膜向内侧移位并侵蚀骨质。结扎后不到2个月，这些胆脂瘤中有一半与耳蜗的骨突接触。结扎诱导的胆脂瘤形成可能是沙鼠特有的。对猫、豚鼠、仓鼠、小鼠和大鼠的外耳道进行类似的结扎会产生角蛋白沉积物。然而，在这些动物中，鼓膜没有向内侧移位，没有胆脂瘤形成，也没有骨质侵蚀。即使在结扎后6至36个月的时间段内，猫、豚鼠、仓鼠、小鼠和大鼠中也未发现胆脂瘤。
