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[青少年慢性关节炎全身型的预后。附100例报告]

[Prognosis of the systemic forms of juvenile chronic arthritis. Apropos of 100 cases].

作者信息

Prieur A M, Brémard-Oury C, Griscelli C, Mozziconacci P

出版信息

Arch Fr Pediatr. 1984 Feb;41(2):91-7.

PMID:6721667
Abstract

The records of 100 children presenting with systemic juvenile rheumatoid arthritis were studied retrospectively. The precocity of onset and intensity of initial extra-articular signs did not seem to be correlated with a more severe outcome. On the other hand, the number of arthritides present during the first 6 months seemed to be associated with a different prognosis: the oligo- or abarticular forms generally had a better prognosis. In girls, onset was earlier and remissions were twice more frequent than in boys. Contrary to all other joints, the hip was susceptible of a radiological improvement in 25% of cases. Joint disabilities, especially of the wrist, were initially related to inflammation and pain; secondarily, they were chiefly related to the anatomic evolution, resulting in fusion of the joint spaces. At the last clinical examination after a 10 year's evolution, half of patients were in clinical remission, either without articular sequellae, with sequellae, the most severe of which being the hip involvement; 25% of patients still had systemic symptoms; 25% presented with polyarthritis with persisting biological and articular inflammatory signs.

摘要

对100例系统性幼年类风湿关节炎患儿的记录进行了回顾性研究。发病的早熟程度和初始关节外体征的强度似乎与更严重的预后无关。另一方面,最初6个月内关节炎的数量似乎与不同的预后相关:少关节型或无关节型通常预后较好。女孩发病更早,缓解频率是男孩的两倍。与所有其他关节不同,25%的病例中髋关节在放射学上有改善。关节残疾,尤其是腕关节残疾,最初与炎症和疼痛有关;其次,主要与解剖学演变有关,导致关节间隙融合。在经过10年演变后的最后一次临床检查中,一半的患者处于临床缓解状态,要么没有关节后遗症,要么有后遗症,其中最严重的是髋关节受累;25%的患者仍有全身症状;25%的患者表现为多关节炎,伴有持续的生物学和关节炎症体征。

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1
[Prognosis of the systemic forms of juvenile chronic arthritis. Apropos of 100 cases].[青少年慢性关节炎全身型的预后。附100例报告]
Arch Fr Pediatr. 1984 Feb;41(2):91-7.
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Hip involvement in juvenile rheumatoid arthritis.青少年类风湿关节炎中的髋关节受累情况
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The 4th NextGen Therapies for SJIA and MAS: part 1 the elephant in the room: diagnostic/classification criteria for systemic juvenile idiopathic arthritis and adult-onset still's disease.第 4 次用于 SJIA 和 MAS 的下一代治疗方法:第 1 部分:房间里的大象:全身型幼年特发性关节炎和成人斯蒂尔病的诊断/分类标准。
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Int J Inflam. 2012;2012:271569. doi: 10.1155/2012/271569. Epub 2011 Dec 25.
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Myocarditis as a form of relapse in two patients with adult Still's disease.
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Rheumatol Int. 2010 Jun;30(8):1095-7. doi: 10.1007/s00296-009-1031-3. Epub 2009 Jul 5.
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Blood leukocyte microarrays to diagnose systemic onset juvenile idiopathic arthritis and follow the response to IL-1 blockade.血液白细胞微阵列用于诊断全身型幼年特发性关节炎并监测对白细胞介素-1阻断治疗的反应。
J Exp Med. 2007 Sep 3;204(9):2131-44. doi: 10.1084/jem.20070070. Epub 2007 Aug 27.