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[青少年慢性关节炎全身型的预后。附100例报告]

[Prognosis of the systemic forms of juvenile chronic arthritis. Apropos of 100 cases].

作者信息

Prieur A M, Brémard-Oury C, Griscelli C, Mozziconacci P

出版信息

Arch Fr Pediatr. 1984 Feb;41(2):91-7.

PMID:6721667
Abstract

The records of 100 children presenting with systemic juvenile rheumatoid arthritis were studied retrospectively. The precocity of onset and intensity of initial extra-articular signs did not seem to be correlated with a more severe outcome. On the other hand, the number of arthritides present during the first 6 months seemed to be associated with a different prognosis: the oligo- or abarticular forms generally had a better prognosis. In girls, onset was earlier and remissions were twice more frequent than in boys. Contrary to all other joints, the hip was susceptible of a radiological improvement in 25% of cases. Joint disabilities, especially of the wrist, were initially related to inflammation and pain; secondarily, they were chiefly related to the anatomic evolution, resulting in fusion of the joint spaces. At the last clinical examination after a 10 year's evolution, half of patients were in clinical remission, either without articular sequellae, with sequellae, the most severe of which being the hip involvement; 25% of patients still had systemic symptoms; 25% presented with polyarthritis with persisting biological and articular inflammatory signs.

摘要

对100例系统性幼年类风湿关节炎患儿的记录进行了回顾性研究。发病的早熟程度和初始关节外体征的强度似乎与更严重的预后无关。另一方面,最初6个月内关节炎的数量似乎与不同的预后相关:少关节型或无关节型通常预后较好。女孩发病更早,缓解频率是男孩的两倍。与所有其他关节不同,25%的病例中髋关节在放射学上有改善。关节残疾,尤其是腕关节残疾,最初与炎症和疼痛有关;其次,主要与解剖学演变有关,导致关节间隙融合。在经过10年演变后的最后一次临床检查中,一半的患者处于临床缓解状态,要么没有关节后遗症,要么有后遗症,其中最严重的是髋关节受累;25%的患者仍有全身症状;25%的患者表现为多关节炎,伴有持续的生物学和关节炎症体征。

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