职业性接触苯乙烯后血清胆汁酸浓度升高：这是肝毒性的一个可能迹象吗？
Raised serum bile acid concentrations after occupational exposure to styrene: a possible sign of hepatotoxicity?
作者信息
Edling C, Tagesson C
出版信息
Br J Ind Med. 1984 May;41(2):257-9. doi: 10.1136/oem.41.2.257.
Abstract
Fasting serum concentrations of conjugated bile acids were investigated in 23 men who had been exposed to styrene and compared with the concentrations in 60 non-exposed individuals. Eleven of the exposed subjects had raised concentrations of either cholic acid or chenodeoxycholic acid or both. There were no indications of alcohol abuse, drug intake, or undiagnosed liver disease. It is possible, therefore, that the raised bile acid concentrations were due to exposure to styrene. This would support the concept that occupational exposure to styrene may affect the liver and point to the possibility that raised serum bile acid concentrations might be a sensitive and early indicator of hepatic injury in individuals exposed to organic solvents.
摘要
对23名接触过苯乙烯的男性的空腹血清结合胆汁酸浓度进行了研究，并与60名未接触者的浓度进行了比较。11名接触者的胆酸或鹅去氧胆酸或两者的浓度升高。没有酗酒、药物摄入或未确诊肝病的迹象。因此，胆汁酸浓度升高可能是由于接触苯乙烯所致。这将支持职业性接触苯乙烯可能影响肝脏的观点，并指出血清胆汁酸浓度升高可能是有机溶剂接触者肝损伤的敏感和早期指标。
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本文引用的文献
1
[Trichloroethylene and liver damage].
Zentralbl Arbeitsmed. 1958 Mar;8(3):56-62.
2
Serum cholic and chenodeoxycholic acid conjugates and standard liver function tests in various morphological stages of alcoholic liver disease.
Scand J Gastroenterol. 1980;15(6):657-63. doi: 10.3109/00365528009181512.
3
Styrene exposure and biologic monitoring in FRP boat production plants.
Int Arch Occup Environ Health. 1982 Feb;49(3-4):325-39. doi: 10.1007/BF00377941.
4
Interaction between drugs and solvents as a cause of fatty change in the liver?
Br J Ind Med. 1982 May;39(2):198-9. doi: 10.1136/oem.39.2.198.
5
Car painters' exposure to a mixture of organic solvents. Serum activities of liver enzymes.
Scand J Work Environ Health. 1982 Jun;8(2):137-40. doi: 10.5271/sjweh.2491.
6
Ethanol potentiation of halogenated aliphatic solvent toxicity.
Am Ind Hyg Assoc J. 1966 Jan-Feb;27(1):57-61. doi: 10.1080/00028896609342793.
7
Chlorinated hydrocarbon toxicity. Potentiation by isopropyl alcohol and acetone.
Arch Environ Health. 1974 May;28(5):276-8. doi: 10.1080/00039896.1974.10666486.
8
Radioimmunoassay of conjugated cholyl bile acids in serum.
Gastroenterology. 1973 Nov;65(5):705-11.
9
Isotachophoretic analysis of mandelic acid, phenylglyoxylic acid, hippuric acid and methylhippuric acid in urine after occupational exposure to styrene, toluene and/or xylene.
J Chromatogr. 1977 Feb 21;132(3):469-76. doi: 10.1016/s0021-9673(00)82910-6.
10
Some hygienic and clinical observations on styrene exposure.
Scand J Work Environ Health. 1978;4 Suppl 2:215-9.
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