应激小鼠的肺部迟发型超敏反应。
Lung delayed-type hypersensitivity in stressed mice.
作者信息
Blecha F, Topliff D
出版信息
Can J Comp Med. 1984 Apr;48(2):211-4.
The influence of an immobilization stressor on lung cellular immune responses was studied. Delayed-type hypersensitivity to sheep erythrocytes was used to evaluate in vivo lung cellular immunity. Mice were sensitized intravenously and challenged intratracheally with sheep erythrocytes. Three hours prior to challenge all mice were injected intravenously with chromium-51 labeled mononuclear cells from syngeneic mice. The delayed-type hypersensitivity response was measured by counting the radioactivity within the lung 48 hours after challenge. Immobilization for 2.5 hours immediately before challenge suppressed lung delayed-type hypersensitivity. Adrenalectomy abolished the immobilization-induced decrease in delayed-type hypersensitivity. These data indicate an adrenal gland involvement in stress-induced decreases in lung cellular immune reactions.
研究了固定应激源对肺部细胞免疫反应的影响。采用对绵羊红细胞的迟发型超敏反应来评估体内肺部细胞免疫。小鼠经静脉致敏，然后经气管内注射绵羊红细胞进行激发。在激发前3小时，所有小鼠经静脉注射来自同基因小鼠的铬-51标记单核细胞。通过在激发后48小时计数肺内的放射性来测量迟发型超敏反应。在激发前立即固定2.5小时可抑制肺部迟发型超敏反应。肾上腺切除术消除了固定诱导的迟发型超敏反应降低。这些数据表明肾上腺参与了应激诱导的肺部细胞免疫反应降低。
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