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给予大鼠的1,5-脱水葡萄糖醇的消除情况。

The elimination of 1,5-anhydroglucitol administered to rats.

作者信息

Pitkänen E, Pitkänen O

出版信息

Experientia. 1984 May 15;40(5):463-5. doi: 10.1007/BF01952387.

DOI:10.1007/BF01952387
PMID:6723908
Abstract

Rat serum contains natural 1,5-anhydroglucitol. Injected or orally administered 1,5-anhydroglucitol was efficiently reabsorbed by the renal tubuli via a mechanism which had a saturation point at high serum 1,5- anhydroglucitol levels. The compound had a slow turnover rate in the body; its half-life is approximately 3 days. The compound was readily absorbed in the gut when administered orally.

摘要

大鼠血清中含有天然1,5-脱水葡萄糖醇。注射或口服的1,5-脱水葡萄糖醇可通过一种在高血清1,5-脱水葡萄糖醇水平时具有饱和点的机制被肾小管有效重吸收。该化合物在体内的周转速度较慢;其半衰期约为3天。口服给药时,该化合物很容易在肠道被吸收。

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本文引用的文献

1
Feeding and hyperglycemia induced by 1,5-anhydroglucitol in the rat.
Physiol Behav. 1981 Sep;27(3):401-5. doi: 10.1016/0031-9384(81)90323-1.
2
Serum 1,5-anhydroglucitol in normal subjects and in patients with insulin-dependent diabetes mellitus.
Scand J Clin Lab Invest. 1982 Sep;42(5):445-8. doi: 10.1080/00365518209168111.
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Occurrence of I,5-anhydroglucitol in human cerebrospinal fluid.1,5-脱水葡萄糖醇在人脑脊液中的出现情况。
Clin Chim Acta. 1973 Oct 12;48(2):159-66. doi: 10.1016/0009-8981(73)90361-6.
4
糖尿病患者血浆1,5-脱水葡萄糖醇(1-脱氧葡萄糖)浓度的降低
Diabetologia. 1988 Jan;31(1):41-5. doi: 10.1007/BF00279131.
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Urinary excretion of 1,5-anhydro-D-glucitol accompanying glucose excretion in diabetic patients.糖尿病患者中伴随葡萄糖排泄的1,5-脱水-D-葡萄糖醇的尿排泄情况。
Diabetologia. 1988 Nov;31(11):831-5. doi: 10.1007/BF00277486.
5
Plasma 1,5-anhydroglucitol in experimental galactosemia in the rat.大鼠实验性半乳糖血症中的血浆1,5-脱水葡萄糖醇
Experientia. 1990 Jan 15;46(1):85-7. doi: 10.1007/BF01955424.
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Renal tubular reabsorption of 1,5-anhydro-D-glucitol and D-mannose in vivo in the rat.大鼠体内1,5-脱水-D-葡萄糖醇和D-甘露糖的肾小管重吸收
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Variation in polyol levels in cerebrospinal fluid and serum in diabetic patients.糖尿病患者脑脊液和血清中多元醇水平的变化。
Diabetologia. 1975 Dec;11(6):575-80. doi: 10.1007/BF01222109.
5
Gas-chromatographic determination of polyol profiles in cerebrospinal fluid.脑脊液中多元醇谱的气相色谱测定
Clin Chem. 1978 Apr;24(4):545-8.