Kaji K, Seyama Y, Yamashita S
Nihon Yakurigaku Zasshi. 1984 Mar;83(3):255-61.
A screening method for the hypolipidemic effect of iodine egg and its active fractions have been investigated with Wistar strain male rats fed on a cholesterol-rich diet. The animals were kept on the cholesterol-rich diet for 5 days, and then iodine egg was fed to them in addition to the above diet for 10 more days. The present method was the most adequate for screening the hypolipidemic effect. Iodine egg yolk was fractionated into the following 3 fractions by Folch's method: Protein ( IEY -P), water-soluble ( IEY -A) and lipid ( IEY -L) fractions. The hypolipidemic effect of these fractions was determined with the screening method. The marked hypolipidemic effect was induced by the IEY -L fraction. The serum total cholesterol level in rats that received the fraction was 57% as compared with that of the ch group (fed on the cholesterol-rich diet). The other groups showed no such effect. Serum thyroid hormone levels were not affected by the IEY -L fraction which was found to be the active hypolipidemic fraction of iodine egg. The thyroid gland did not seem to participate directly in such a hypolipidemic effect.
采用喂饲富含胆固醇饲料的Wistar雄性大鼠，对碘蛋及其活性成分的降血脂作用进行了筛选方法的研究。动物先喂饲富含胆固醇的饲料5天，然后在此基础上再喂饲碘蛋10天。本方法最适合于筛选降血脂作用。用Folch法将碘蛋黄分为以下3个部分：蛋白质（IEY-P）、水溶性（IEY-A）和脂质（IEY-L）部分。用该筛选方法测定这些部分的降血脂作用。IEY-L部分诱导出显著的降血脂作用。接受该部分的大鼠血清总胆固醇水平与ch组（喂饲富含胆固醇饲料）相比为57%。其他组未显示出这种作用。血清甲状腺激素水平不受IEY-L部分的影响，该部分被发现是碘蛋的活性降血脂部分。甲状腺似乎未直接参与这种降血脂作用。
