Corwin R M, Pratt S E, Muser R K
J Am Vet Med Assoc. 1984 Jul 1;185(1):58-9.
Fenbendazole was given in the feed to swine at a cumulative dosage of 9 mg/kg of body weight over a period of 3, 6, and 12 days to compare efficacy. Four treatment groups of ten 2- to 3-month-old pigs each, with a mean of 15 kg of body weight per group, received 3 mg of fenbendazole/kg/day for 3 days, 1.5 mg/kg/day for 6 days, 0.75 mg/kg/day for 12 days, and no medication. Medicated feed was scheduled so that all treated pigs reached the last day of treatment on the same day, thus making the time between the last treatment and necropsy equal for all groups. Ascaris suum and Trichuris suis were the target species, their presence before treatment being determined by fecal egg counts and at necropsy by worm counts. At necropsy, 9 control pigs were infected with A suum (mean of 18.0 worms/pig), and all control pigs had T suis infection (mean of 36.5 worms/pig). All 3 treatment schedules were 100% effective in removal of A suum; and for T suis, the 3-day regimen was 100% effective, the 6-day regimen, 99.2%, and the 12-day regimen, 91.0%.
将芬苯达唑添加到猪的饲料中，在3天、6天和12天的时间内累计剂量为9毫克/千克体重，以比较疗效。四个治疗组，每组十头2至3月龄的猪，每组平均体重15千克，分别接受3毫克芬苯达唑/千克/天，持续3天；1.5毫克/千克/天，持续6天；0.75毫克/千克/天，持续12天，以及不进行药物治疗。安排用药饲料，以便所有接受治疗的猪在同一天达到治疗的最后一天，从而使所有组在最后一次治疗和尸检之间的时间相等。猪蛔虫和猪鞭虫是目标物种，治疗前它们的存在通过粪便虫卵计数确定，尸检时通过虫体计数确定。尸检时，9头对照猪感染了猪蛔虫（平均每头猪18.0条虫），所有对照猪都感染了猪鞭虫（平均每头猪36.5条虫）。所有三种治疗方案对清除猪蛔虫均100%有效；对于猪鞭虫，3天疗程的有效率为100%，6天疗程为99.2%，12天疗程为91.0%。
