Nakano Y, Oomura Y, Nishino H, Aou S, Yamamoto T, Nemoto S
Brain Res Bull. 1984 Apr;12(4):381-5. doi: 10.1016/0361-9230(84)90109-6.
To investigate neuronal responses to interoceptive information, single neuron activity of the orbitofrontal cortex (OBF) of the behaving monkey was recorded during glucose injection, natural feeding and an operant bar press feeding task. Intravenous glucose injection had almost no effect on rates of spontaneous firing, but tended to attenuate neuronal responses during the bar press and reward periods. In about half of the neurons tested, the spontaneous firing rate changed for a relatively long period after the animal ate to satiety. The results suggest that blood glucose concentration is a modulatory factor in neuronal processing for feeding, but other interoceptive information generated by satiety strongly affects the activity of OBF neurons.
为了研究神经元对内感受信息的反应，在给行为猴注射葡萄糖、自然进食以及操作性压杆进食任务期间，记录了其眶额叶皮质（OBF）的单神经元活动。静脉注射葡萄糖对自发放电频率几乎没有影响，但往往会减弱压杆和奖励期间的神经元反应。在大约一半接受测试的神经元中，动物进食至饱腹感后，自发放电频率在较长一段时间内发生了变化。结果表明，血糖浓度是进食神经元处理过程中的一个调节因素，但饱腹感产生的其他内感受信息强烈影响眶额叶皮质神经元的活动。
