Bove A A, Dewey J D, Tyce G M
J Lab Clin Med. 1984 Jul;104(1):77-85.
To evaluate the effect of endurance exercise on plasma catecholamines, we exercise trained eight dogs (group T) by treadmill running for 8 weeks. Six sedentary dogs constituted a nontrained control group (group NT). Heart rate response to a graded submaximal stress test was reduced in group T dogs (p less than 0.05), but mean resting aortic blood pressure (NT, 84 +/- 5 mm Hg; T, 82 +/- 4 mm Hg) and heart rate (NT, 87 +/- 1 bpm; T, 84 +/- 2 bpm) were unchanged by exercise, and no cardiac hypertrophy occurred after exercise. Plasma norepinephrine and epinephrine levels were reduced in group T at rest and during a fixed exercise workload. Plasma conjugated dopamine showed a marked increase in group T dogs (NT, 1398 +/- 130 pg/ml; T, 11346 +/- 1291 pg/ml; p less than 0.01) at rest, and no change in conjugated dopamine occurred in either group after short-term exercise stress. No intergroup differences were noted in resting coronary flow or coronary arteriovenous oxygen, or in myocardial oxygen consumption. The data verify previous findings of lower plasma levels of norepinephrine and epinephrine after training, and indicate that a marked rise in conjugated dopamine occurs after training. These findings suggest that norepinephrine and epinephrine metabolism is shifted toward conjugated dopamine by exercise training, thereby reducing active catecholamines in plasma, but retaining a large pool of usable metabolite.
为评估耐力运动对血浆儿茶酚胺的影响，我们通过跑步机跑步对8只犬（T组）进行了8周的运动训练。6只 sedentary犬组成未训练对照组（NT组）。T组犬对分级次极量应激试验的心率反应降低（p<0.05），但静息主动脉平均血压（NT组，84±5 mmHg；T组，82±4 mmHg）和心率（NT组，87±1次/分钟；T组，84±2次/分钟）未因运动而改变，且运动后未发生心肌肥大。T组静息时及固定运动负荷期间血浆去甲肾上腺素和肾上腺素水平降低。T组犬静息时血浆结合多巴胺显著升高（NT组，1398±130 pg/ml；T组，11346±1291 pg/ml；p<0.01），短期运动应激后两组结合多巴胺均无变化。静息冠脉血流量、冠脉动静脉氧含量或心肌氧耗量在两组间无差异。这些数据证实了先前关于训练后血浆去甲肾上腺素和肾上腺素水平降低的发现，并表明训练后结合多巴胺显著升高。这些发现提示，运动训练使去甲肾上腺素和肾上腺素代谢向结合多巴胺转变，从而降低血浆中活性儿茶酚胺水平，但保留大量可用代谢物。
