着色性干皮病中一些作用于DNA的酶的水平。
Levels of some enzymes acting on DNA in xeroderma pigmentosum.
作者信息
Pedrini A M, Dalpra L, Ciarrocchi G, Noy G C, Spadari S, Nuzzo F, Falaschi A
出版信息
Nucleic Acids Res. 1974 Feb;1(2):193-202. doi: 10.1093/nar/1.2.193.
Abstract
We have determined the levels of DNA polymerase, DNA ligase, a DNase acting on single-stranded DNA, an endonuclease making single-strand breaks in double - stranded DNA and polynucleotide kinase in fibroblasts obtained from nine normal persons and from nine patients with Xeroderma Pigmentosum; the pathological lines belong to the different described clinical forms and to the three different complementation groups described so far. All the enzymes are present in the normal lines and in the Xeroderma lines. The levels are quite variable, but the values obtained in the pathological lines lie within the ones observed in the normal population.
摘要
我们已经测定了从9名正常人及9名色素性干皮病患者的成纤维细胞中提取的DNA聚合酶、DNA连接酶、一种作用于单链DNA的脱氧核糖核酸酶、一种在双链DNA中产生单链断裂的内切核酸酶以及多核苷酸激酶的水平；这些病理细胞系属于不同描述的临床类型以及迄今描述的三个不同互补组。所有这些酶在正常细胞系和色素性干皮病细胞系中均有存在。其水平变化很大，但在病理细胞系中获得的值处于正常人群中观察到的值范围内。
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Levels of some enzymes acting on DNA in xeroderma pigmentosum.着色性干皮病中一些作用于DNA的酶的水平。
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引用本文的文献
1
An altered apurinic DNA endonuclease activity in group A and group D xeroderma pigmentosum fibroblasts.A组和D组着色性干皮病成纤维细胞中脱嘌呤DNA内切酶活性改变。
Proc Natl Acad Sci U S A. 1976 Apr;73(4):1169-73. doi: 10.1073/pnas.73.4.1169.
2
Levels of DNA polymerase-alpha and beta in normal and xeroderma pigmentosum fibroblasts.正常及着色性干皮病成纤维细胞中DNA聚合酶α和β的水平
Nucleic Acids Res. 1977 Jan;4(1):141-8. doi: 10.1093/nar/4.1.141.
3
DNA polymerases alpha beta and gamma in inherited diseases affecting DNA repair.影响DNA修复的遗传性疾病中的DNA聚合酶α、β和γ
Nucleic Acids Res. 1978 Jun;5(6):2189-96. doi: 10.1093/nar/5.6.2189.
本文引用的文献
1
Defective repair replication of DNA in xeroderma pigmentosum.着色性干皮病中DNA修复复制缺陷。
Nature. 1968 May 18;218(5142):652-6. doi: 10.1038/218652a0.
2
Phosphorylation of nucleic acid by an enzyme from T4 bacteriophage-infected Escherichia coli.来自T4噬菌体感染的大肠杆菌的一种酶对核酸的磷酸化作用。
Proc Natl Acad Sci U S A. 1965 Jul;54(1):158-65. doi: 10.1073/pnas.54.1.158.
3
Evidence that xeroderma pigmentosum cells do not perform the first step in the repair of ultraviolet damage to their DNA.着色性干皮病细胞在修复其DNA紫外线损伤时不执行第一步的证据。
Proc Natl Acad Sci U S A. 1969 Nov;64(3):1035-41. doi: 10.1073/pnas.64.3.1035.
4
Xeroderma pigmentosum: a human disease in which an initial stage of DNA repair is defective.着色性干皮病：一种人类疾病，其DNA修复的初始阶段存在缺陷。
Proc Natl Acad Sci U S A. 1969 Jun;63(2):428-35. doi: 10.1073/pnas.63.2.428.
5
Purification and properties of a polynucleotide ligase from human cell cultures.来自人细胞培养物的多核苷酸连接酶的纯化及性质
Eur J Biochem. 1971 Sep 13;22(1):75-8. doi: 10.1111/j.1432-1033.1971.tb01516.x.
6
Induction of polynucleotide ligase in human lymphocytes stimulated by phytohemoagglutinin.植物血凝素刺激的人淋巴细胞中多核苷酸连接酶的诱导。
Biochem Biophys Res Commun. 1972 Jun 9;47(5):1221-7. doi: 10.1016/0006-291x(72)90965-5.
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UV-induced DNA repair synthesis in cells of patients with different forms of xeroderma pigmentosum and of heterozygotes.不同类型着色性干皮病患者及杂合子细胞中紫外线诱导的DNA修复合成
Mutat Res. 1973 Dec;20(3):417-28. doi: 10.1016/0027-5107(73)90062-6.
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Effects of inhibitors on repair of DNA in normal human and xeroderma pigmentosum cells after exposure to x-rays and ultraviolet irradiation.抑制剂对正常人细胞和着色性干皮病细胞在X射线和紫外线照射后DNA修复的影响。
Mutat Res. 1973 Mar;17(3):385-94. doi: 10.1016/0027-5107(73)90010-9.
9
Genetic heterogeneity of xeroderma pigmentosum demonstrated by somatic cell hybridization.通过体细胞杂交证明的着色性干皮病的遗传异质性。
Nat New Biol. 1972 Jul 19;238(81):80-3. doi: 10.1038/newbio238080a0.
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A UV-specific endonucleolytic activity present in human cell extracts.人类细胞提取物中存在的一种紫外线特异性核酸内切酶活性。
Biochem Biophys Res Commun. 1972 Aug 7;48(3):662-9. doi: 10.1016/0006-291x(72)90399-3.
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