Kekki M, Sipponen P, Siurala M
Scand J Gastroenterol. 1984 May;19(3):382-8.
The dynamics of the antral and body mucosa has been studied in biopsy specimens obtained during endoscopy of patients with duodenal ulcer (103 cases), patients with duodenal ulcer scars (108 cases), and patients with duodenitis (44 cases). A representative Finnish population sample consisting of 434 subjects was used as reference material. The antral mucosa of all patient series showed an increase in the severity and prevalence of gastritis similar to that of the general population, whereas virtually no progression of gastritis with age was seen in the body mucosa, which remained normal or at the stage of superficial gastritis up to geriatric age. In contrast, in the present controls and in all earlier population samples studied by us so far, there was a significant and steady increase in the severity and prevalence of body gastritis with age. It is concluded that the age behavior of the antral and body mucosa was in duodenal ulcer scars and duodenitis similar to that of patients with active duodenal ulcer. The persistence of normal conditions in the acid-secreting area may serve as one explanation of the strong tendency of the disease to recur. In addition, it is tentatively concluded that in duodenal ulcer disease there are factors that have a 'protecting' influence on the body glands and which are abolished by antrectomy, according to our earlier studies.
对十二指肠溃疡患者（103例）、十二指肠溃疡瘢痕患者（108例）和十二指肠炎患者（44例）在内镜检查时获取的活检标本中的胃窦和胃体黏膜动态变化进行了研究。选取了由434名受试者组成的具有代表性的芬兰人群样本作为参考材料。所有患者组的胃窦黏膜均显示出与普通人群相似的胃炎严重程度和患病率增加，而胃体黏膜几乎未见随年龄增长的胃炎进展，直至老年期仍保持正常或处于浅表性胃炎阶段。相比之下，在目前的对照组以及我们迄今为止研究的所有早期人群样本中，胃体胃炎的严重程度和患病率均随年龄显著且持续增加。得出的结论是，十二指肠溃疡瘢痕和十二指肠炎患者的胃窦和胃体黏膜的年龄变化情况与活动性十二指肠溃疡患者相似。胃酸分泌区域正常状态的持续存在可能是该疾病强烈复发倾向的一种解释。此外，根据我们早期的研究初步得出结论，在十二指肠溃疡疾病中存在对胃体腺体有“保护”作用的因素，而这些因素会因胃窦切除术而被消除。
