不溶性改性聚苯乙烯的抗血栓性能：第一部分

Antithrombic properties of insoluble modified polystyrene: Part I.

作者信息

Boisson C, Gulino D, Jozefonvicz J, Fischer A M, Tapon-Bretaudiere J

出版信息

Thromb Res. 1984 May 15;34(4):269-76. doi: 10.1016/0049-3848(84)90383-9.

Abstract

Chlorosulfonated polystyrenes grafted with arginyl methyl ester have been synthetized and characterized by elemental analyses. When suspended in plasma or in fibrinogen solutions, these insoluble polymers cause an increase in the thrombin clotting time. Consequently the antithrombin activity observed is not dependent upon to the presence of antithrombin III. Binding between the resin and thrombin can be demonstrated. An approximative value of the affinity constant is calculated: 2.3 X 10(6) 1/M. At high ionic strength, thrombin can be desorbed and exhibits normal coagulation properties. The prolongation of the thrombin time therefore can be attributed to the thrombin-resin interaction.

摘要

已合成了接枝有精氨酰甲酯的氯磺化聚苯乙烯，并通过元素分析对其进行了表征。当悬浮于血浆或纤维蛋白原溶液中时，这些不溶性聚合物会导致凝血酶凝血时间延长。因此，观察到的抗凝血酶活性并不依赖于抗凝血酶III的存在。可以证明树脂与凝血酶之间存在结合。计算出亲和常数的近似值：2.3×10⁶ 1/M。在高离子强度下，凝血酶可以解吸并表现出正常的凝血特性。因此，凝血酶时间的延长可归因于凝血酶与树脂的相互作用。