Wilkie D R, Dawson M J, Edwards R H, Gordon R E, Shaw D
Adv Exp Med Biol. 1984;170:333-47. doi: 10.1007/978-1-4684-4703-3_28.
Study of human tissues using 31P topical Magnetic Resonance is completely atraumatic; it allows simultaneous measurement of the concentrations of many important metabolites and of intracellular pH. In some critical situations, TMR yields more accurate results than those obtained by chemical analysis of tissue biopsies. We have shown that TMR can be calibrated to obtain quantitative measurements in human subjects. We have also shown that theories of control of glycolysis based on regulation by key metabolites of rate-limiting enzymes are inconsistent with the observed changes in intact muscle.
使用31P局部磁共振对人体组织进行研究完全无创；它能够同时测量多种重要代谢物的浓度以及细胞内pH值。在某些关键情况下，与通过组织活检化学分析所获得的结果相比，31P局部磁共振能产生更准确的结果。我们已经表明，31P局部磁共振可以进行校准以在人体受试者中获得定量测量结果。我们还表明，基于限速酶关键代谢物调节的糖酵解控制理论与在完整肌肉中观察到的变化不一致。
