Ekerdt D J, Sparrow D, Glynn R J, Bossé R
Am J Epidemiol. 1984 Jul;120(1):64-71. doi: 10.1093/oxfordjournals.aje.a113875.
This study examines change in systolic blood pressure, diastolic blood pressure, and total serum cholesterol over a three-year span in two groups of men aged 55-74 years at follow-up: 1) 262 men who were working at baseline but retired at follow-up, and 2) 409 age peers who remained employed at both measurement times. Measures were obtained from medical examinations conducted since the early 1970s as part of the prospective Veterans Administration Normative Aging Study in Boston. Regression analyses showed an average increase of 3.44 mmHg in systolic blood pressure, 1.62 mmHg in diastolic blood pressure, and 5.56 mg/dl in cholesterol for retirees compared with workers. The relative increases in the blood pressure variables were statistically significant. However, a logistic regression analysis did not show a greater incidence of hypertension among retirees compared with workers. The odds ratio, standardized for baseline blood pressure, body mass index, and age, was 0.90 (95 per cent confidence interval 0.56-1.45). Among retirees only, analyses of covariance showed that levels of blood pressure and cholesterol were comparable from one six-month interval to the next in the three years preceding and following retirement. Overall, the effects of retirement were not of sufficient magnitude to conclude that retirement had a clinically significant impact on blood pressure or cholesterol.
本研究调查了两组年龄在55 - 74岁的男性在三年随访期内收缩压、舒张压和血清总胆固醇的变化情况:1)262名男性在基线时在职,但在随访时退休;2)409名同龄男性在两次测量时均在职。这些测量数据来自自20世纪70年代初以来进行的医学检查,作为波士顿退伍军人管理局前瞻性规范衰老研究的一部分。回归分析显示,与在职人员相比,退休人员的收缩压平均升高3.44 mmHg,舒张压平均升高1.62 mmHg,胆固醇平均升高5.56 mg/dl。血压变量的相对升高具有统计学意义。然而,逻辑回归分析显示,与在职人员相比,退休人员中高血压的发病率并未更高。在对基线血压、体重指数和年龄进行标准化后,优势比为0.90(95%置信区间为0.56 - 1.45)。仅在退休人员中,协方差分析显示,在退休前和退休后的三年中,血压和胆固醇水平在相邻的六个月间隔内具有可比性。总体而言,退休的影响程度不足以得出退休对血压或胆固醇有临床显著影响的结论。