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从肾皮质组织中提取氨基糖苷类药物的改进方法。

Improved procedure for extracting aminoglycosides from renal cortical tissue.

作者信息

Giuliano R A, Verpooten G A, Pollet D E, Verbist L, Scharpé S L, De Broe M E

出版信息

Antimicrob Agents Chemother. 1984 Jun;25(6):783-4. doi: 10.1128/AAC.25.6.783.

DOI:10.1128/AAC.25.6.783
PMID:6742820
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC185644/
Abstract

An efficient and reproducible procedure was developed for extracting aminoglycosides from renal cortical tissue. It involves a double homogenization and two rinsings with trichloroacetic acid. A higher recovery is obtained compared with that of other previously reported methods.

摘要

开发了一种从肾皮质组织中提取氨基糖苷类药物的高效且可重复的方法。该方法包括双重匀浆和用三氯乙酸进行两次冲洗。与其他先前报道的方法相比，回收率更高。

相似文献

1
Improved procedure for extracting aminoglycosides from renal cortical tissue.从肾皮质组织中提取氨基糖苷类药物的改进方法。
Antimicrob Agents Chemother. 1984 Jun;25(6):783-4. doi: 10.1128/AAC.25.6.783.
2
Micellar Electrokinetic Chromatography of Aminoglycosides.氨基糖苷类药物的胶束电动色谱法。
Methods Mol Biol. 2016;1483:77-90. doi: 10.1007/978-1-4939-6403-1_5.
3
[Habekacin: a new aminoglycoside. Study of nephrotoxicity in rats in comparison with gentamicin, netilmicin and amikacin].[哈贝卡星：一种新型氨基糖苷类抗生素。与庆大霉素、奈替米星和阿米卡星相比对大鼠肾毒性的研究]
Pathol Biol (Paris). 1988 Jun;36(6):795-800.
4
Comparative effects of aminoglycosides on renal cortical and urinary phospholipids in the rat.氨基糖苷类药物对大鼠肾皮质和尿中磷脂的比较效应。
Proc Soc Exp Biol Med. 1986 May;182(1):1-5. doi: 10.3181/00379727-182-42300.
5
In vivo uptake kinetics of aminoglycosides in the kidney cortex of rats.氨基糖苷类药物在大鼠肾皮质中的体内摄取动力学。
J Pharmacol Exp Ther. 1986 Feb;236(2):470-5.
6
Comparative nephrotoxicity of hydroxygentamicin and other aminoglycosides in rats.庆大霉素与其他氨基糖苷类药物对大鼠的肾毒性比较
Fundam Appl Toxicol. 1984 Aug;4(4):558-67. doi: 10.1016/0272-0590(84)90045-9.
7
Aminoglycosides induce a phospholipidosis in the renal cortex of the rat: an early manifestation of nephrotoxicity.
J Pharmacol Exp Ther. 1982 Mar;220(3):514-20.
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[Functional, histological, biochemical renal modifications. Comparative study of dibekacin, gentamicin, tobramycin, netilmicin and amikacin].[肾脏的功能、组织学及生化改变。地贝卡星、庆大霉素、妥布霉素、奈替米星和阿米卡星的比较研究]
Nouv Presse Med. 1982 Nov 18;11(46):3419-25.
9
Role of megalin in renal handling of aminoglycosides.巨蛋白在肾脏处理氨基糖苷类药物中的作用。
Am J Physiol Renal Physiol. 2001 Aug;281(2):F337-44. doi: 10.1152/ajprenal.2001.281.2.F337.
10
Effect of netilmicin on the phospholipid composition of subcellular fractions of rat renal cortex.
J Pharmacol Exp Ther. 1985 Dec;235(3):810-9.

引用本文的文献

1
Renal cortical kinetics of gentamicin after implantation of gentamicin-polymethylmethacrylate beads in rats.庆大霉素-聚甲基丙烯酸甲酯珠植入大鼠后庆大霉素的肾皮质动力学
Antimicrob Agents Chemother. 1986 Sep;30(3):385-9. doi: 10.1128/AAC.30.3.385.
2
New sodium hydroxide digestion method for measurement of renal tobramycin concentrations.用于测量肾脏中妥布霉素浓度的新型氢氧化钠消化法。
Antimicrob Agents Chemother. 1986 Sep;30(3):361-5. doi: 10.1128/AAC.30.3.361.
3
Improved sodium hydroxide digestion method without homogenization for extraction of gentamicin from renal tissue.改良的无需匀浆的氢氧化钠消化法用于从肾组织中提取庆大霉素。
Antimicrob Agents Chemother. 1988 Apr;32(4):595-7. doi: 10.1128/AAC.32.4.595.
4
Total extraction of aminoglycosides from guinea pig and bullfrog tissues with sodium hydroxide or trichloroacetic acid.用氢氧化钠或三氯乙酸从豚鼠和牛蛙组织中完全提取氨基糖苷类。
Antimicrob Agents Chemother. 1989 Apr;33(4):448-51. doi: 10.1128/AAC.33.4.448.
5
Effect of isepamicin dosing scheme on concentration in cochlear tissue.异帕米星给药方案对耳蜗组织中浓度的影响。
Antimicrob Agents Chemother. 1991 Nov;35(11):2401-6. doi: 10.1128/AAC.35.11.2401.

本文引用的文献

1
Influence of dose regimen on renal accumulation of aminoglycosides.给药方案对氨基糖苷类药物肾脏蓄积的影响。
Arch Int Pharmacodyn Ther. 1982 Dec;260(2):277-9.
2
Binding of antibiotics to tissue homogenates.抗生素与组织匀浆的结合
J Infect Dis. 1970 Jan;121(1):55-64. doi: 10.1093/infdis/121.1.55.
3
Distribution of gentamicin and amikacin in rabbit tissues.庆大霉素和阿米卡星在兔组织中的分布。
Antimicrob Agents Chemother. 1977 Jun;11(6):974-7. doi: 10.1128/AAC.11.6.974.
4
Stability of dilute solutions of gentamicin and tobramycin.庆大霉素和妥布霉素稀释溶液的稳定性。
Clin Chem. 1979 Feb;25(2):298-300.
5
Comparative nephrotoxicity of aminoglycoside antibiotics in rats.氨基糖苷类抗生素对大鼠的比较肾毒性
J Infect Dis. 1978 Oct;138(4):541-5. doi: 10.1093/infdis/138.4.541.
6
Nephrotoxicity of gentamicin and tobramycin given once daily or continuously in dogs.庆大霉素和妥布霉素每日一次或持续给药对犬的肾毒性
J Antimicrob Chemother. 1978 May;4 Suppl A:85-101. doi: 10.1093/jac/4.suppl_a.85.
7
Gentamicin disposition and tissue accumulation on multiple dosing.
J Pharmacokinet Biopharm. 1977 Dec;5(6):559-77. doi: 10.1007/BF01059684.
8
Comparative nephrotoxicities of gentamicin, netilmicin and tobramycin in the rat.庆大霉素、奈替米星和妥布霉素对大鼠的肾毒性比较
J Pharmacol Exp Ther. 1979 Sep;210(3):334-43.