Sandler R S, Johnson M D, Holland K L
Dig Dis Sci. 1984 Aug;29(8):703-8. doi: 10.1007/BF01312941.
Patients with previous gastric surgery for benign conditions are thought to be at increased risk for gastric cancer based on studies from Europe. Recommendations have been made to screen these patients repeatedly in order to detect early gastric cancers. We conducted a case-control study to estimate the risk in the United States where the rates of gastric cancer are lower. There were 521 gastric cancer cases who were matched by age, race, sex, and date of admission to an equal number of hospital controls. The odds ratio for cancer after gastric surgery was 0.7 (P = 0.4) which indicates no increased risk. The sample size was sufficient to detect risks in the range reported in previous studies. The odds ratios rose with longer postoperative intervals but were based on small numbers and were not statistically significant. This case-control study failed to demonstrate an overall increased risk for gastric cancer after surgery. Further study is needed before general screening can be endorsed in the United States.
基于欧洲的研究，曾因良性疾病接受过胃部手术的患者被认为患胃癌的风险增加。已有人建议对这些患者进行反复筛查，以便检测早期胃癌。我们开展了一项病例对照研究，以评估胃癌发病率较低的美国的此类风险。共有521例胃癌病例，按照年龄、种族、性别和入院日期与数量相等的医院对照进行匹配。胃部手术后患癌的比值比为0.7（P = 0.4），这表明风险并未增加。样本量足以检测先前研究报告范围内的风险。比值比随术后间隔时间延长而升高，但基于的样本数量较少，且无统计学意义。这项病例对照研究未能证明手术后胃癌总体风险增加。在美国批准进行普遍筛查之前，还需要进一步研究。
