Acker G M, Galen F X, Devaux C, Foote S, Papernik E, Pesty A, Menard J, Corvol P
J Clin Endocrinol Metab. 1982 Nov;55(5):902-9. doi: 10.1210/jcem-55-5-902.
Amnion and chorion cells from human fetal membranes have been cultured. Chorionic cells secrete renin whereas amnionic cells do not. Renin is secreted by chorionic cells as an inactive form that can be activated by trypsin treatment or acid dialysis. The antigenic and enzymatic properties of activated chorionic renin and kidney renin are similar. Incorporation of [35S]methionine in the culture demonstrates that chorionic renin is secreted as a high molecular weight form, 54K. This 54K inactive renin could represent the proenzyme.
人胎膜的羊膜细胞和绒毛膜细胞已被培养。绒毛膜细胞分泌肾素，而羊膜细胞不分泌。绒毛膜细胞分泌的肾素以无活性形式存在，可通过胰蛋白酶处理或酸透析激活。激活的绒毛膜肾素和肾脏肾素的抗原性和酶活性相似。在培养物中掺入[35S]甲硫氨酸表明，绒毛膜肾素以54K的高分子量形式分泌。这种54K无活性肾素可能代表酶原。
