Jacobs M R, Kelly F, Speck W T
Antimicrob Agents Chemother. 1982 Nov;22(5):897-900. doi: 10.1128/AAC.22.5.897.
The susceptibility of 100 group B streptococci to 16 beta-lactam antibiotics was tested by agar dilution. Penicillin G and N-formimidoyl thienamycin were the most active agents tested, both having a 90% minimal inhibitory concentration (MIC90) of 0.06 microgram/ml. Ceftriaxone, cefotaxime, cefamandole, and SCH 29482 were almost as active, all having an MIC90 of 0.12 microgram/ml, and ampicillin, cephalothin, and mezlocillin all had an MIC90 of 0.25 microgram/ml. The MIC90 for piperacillin, cefoperazone, and ceftazidime was 0.5 microgram/ml. Least active were carbenicillin, ticarcillin, cefoxitin, and moxalactam, with MIC90s of 1, 2, 4, and 8 micrograms/ml, respectively. No penicillin-tolerant strains were detected.
采用琼脂稀释法检测了100株B组链球菌对16种β-内酰胺类抗生素的敏感性。青霉素G和N-甲酰亚胺硫霉素是检测的活性最强的药物，二者的90%最小抑菌浓度（MIC90）均为0.06微克/毫升。头孢曲松、头孢噻肟、头孢孟多和SCH 29482的活性几乎相同，MIC90均为0.12微克/毫升，氨苄西林、头孢噻吩和美洛西林的MIC90均为0.25微克/毫升。哌拉西林、头孢哌酮和头孢他啶的MIC90为0.5微克/毫升。活性最低的是羧苄西林、替卡西林、头孢西丁和莫拉卡坦，MIC90分别为1、2、4和8微克/毫升。未检测到耐青霉素菌株。
